June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Prevalence and risk factors of retinal vein occlusion in Asian Indians - comparative study between Singapore and India
Author Affiliations & Notes
  • Mayuri Bhargava
    Singapore Eye Research Institute, Singapore, Singapore
    Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • Victor Koh
    Singapore Eye Research Institute, Singapore, Singapore
    Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • Carol Cheung
    Singapore Eye Research Institute, Singapore, Singapore
    Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • Wan Ling Wong
    Singapore Eye Research Institute, Singapore, Singapore
  • Jie Wang
    Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Centre for Eye Research Australia, University of Melbourne, Australia, Singapore, Singapore
  • Paul Mitchell
    Centre for Eye Research Australia, University of Melbourne, Australia, Singapore, Singapore
  • Tin Aung
    Singapore Eye Research Institute, Singapore, Singapore
    Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • Tien Wong
    Singapore Eye Research Institute, Singapore, Singapore
    Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • Footnotes
    Commercial Relationships Mayuri Bhargava, None; Victor Koh, None; Carol Cheung, None; Wan Ling Wong, None; Jie Wang, None; Paul Mitchell, Novartis (R), Bayer (R); Tin Aung, Alcon (R), Alcon (C), Alcon (F), Allergan (R), Allergan (C), Carl Zeiss Meditec (F), Carl Zeiss Meditec (R), Ellex (F), Ellex (R), Santen (R); Tien Wong, Allergan (C), Bayer (C), Novartis (C), Pfizer (C), GSK (F), Roche (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1565. doi:
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      Mayuri Bhargava, Victor Koh, Carol Cheung, Wan Ling Wong, Jie Wang, Paul Mitchell, Tin Aung, Tien Wong; Prevalence and risk factors of retinal vein occlusion in Asian Indians - comparative study between Singapore and India. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1565.

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Abstract

Purpose: To describe the prevalence of retinal vein occlusion (RVO) and its risk factors in Asian Indians - comparative study between Singapore and India

Methods: The Singapore Indian Eye (SINDI) Study is a population-based survey of 3,400 Indians aged between 40 to 80 years staying in urban Singapore. A comprehensive ophthalmic examination, standardized interviews and laboratory blood tests were performed. Digital retinal fundus photographs were assessed for the presence of RVO following the definitions used in the Blue Mountains Eye Study. The results were compared to the Central Indian Eye and Medical Study (CIEMS), a population-based study performed in rural Central India comprising 3424 Indians aged 30 years and above.

Results: A total of 3,173 persons [mean age 57.8 ± (SD) 10.1 years and 50.2% male] provided data in this study. The overall prevalence of retinal vein occlusion was 0.82% (n = 26) (95% confidence interval [CI] 0.71- 0.89%) - 23 branch and 4 central RVO. Older age (odds ratio [OR] 1.05; 95% CI: 1.02, 1.07, per year increase), increasing systolic blood pressure (OR 1.02; 95% CI: 1.01, 1.03, per mmHg increase), hypertension (OR 2.60; 95% CI: 1.22, 5.51), ocular perfusion pressure (OR 1.06; 95% CI: 1.01, 1.12, per mmHg increase) and disc area (OR 2.84; 95% CI: 1.217, 6.33, per mm2 increase) were significantly associated with RVO. There was no significant association between RVO with mass body index, cholesterol, blood glucose, smoking, history of strokes or myocardial infarction. Compared to CIEMS, the association between RVO with older age and hypertension was consistent but no association with disc size was found.

Conclusions: RVOs were detected in 0.82% of the Indian population in Singapore. This was similar to the results of CIEMS (0.76%). Significant factors associated with RVOs in an urban Indian population were older age, increasing systolic blood pressure, hypertension, increasing ocular perfusion pressure and larger disc area.

Keywords: 688 retina • 749 vascular occlusion/vascular occlusive disease  
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