June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Inter- and Intra-Lamellar Slippage of Collagen Fibrils as a Potential Mechanism of Keratoconus Progression
Author Affiliations & Notes
  • Michael Koster
    Institue for Structural Mechanics, Ruhr University Bochum, Bochum, Germany
  • Craig Boote
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • Keith Meek
    School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
  • Priscilla Fowler
    Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • Christopher Girkin
    Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • Guenther Meschke
    Institue for Structural Mechanics, Ruhr University Bochum, Bochum, Germany
  • Rafael Grytz
    Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • Footnotes
    Commercial Relationships Michael Koster, None; Craig Boote, None; Keith Meek, None; Priscilla Fowler, None; Christopher Girkin, SOLX (F), Heidelberg Engineering (F); Guenther Meschke, None; Rafael Grytz, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1642. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Michael Koster, Craig Boote, Keith Meek, Priscilla Fowler, Christopher Girkin, Guenther Meschke, Rafael Grytz; Inter- and Intra-Lamellar Slippage of Collagen Fibrils as a Potential Mechanism of Keratoconus Progression. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1642.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose
 

To assess if inter- and intra-lamellar slippage of collagen fibrils may lead to progressive cone formation in keratoconus.

 
Methods
 

A generic finite element model of the human eye was generated that incorporates the micro-architecture of collagen fibrils in the corneo-scleral shell. Inter- and intra-lamellar slippage was simulated through residual strains of collagen fibrils using a microstructure-based constitutive formulation. Progressive inter- and intra-lamellar slippage was imposed to an eccentric, 4-mm-diameter area of the cornea while the model was subjected to normal IOP (15 mmHg). Topographic results were compared to clinical observation of a keratoconus patient with an eccentric cone.

 
Results
 

Increasing inter- and intra-lamellar slippage led to progressive cone formation of the cornea. The results were in good agreement with topographic observation of keratoconus patients with eccentric cone.

 
Conclusions
 

The numerical results support the assumption that inter- and intra-lamellar slippage of collagen fibrils may be the underlying mechanism that leads to progressive cone formation in keratoconus.

 
 
Numerical simulation of keratoconus progression showing the development of an eccentric cone due to inter- and intra-lamellar slippage of corneal collagen fibrils.
 
Numerical simulation of keratoconus progression showing the development of an eccentric cone due to inter- and intra-lamellar slippage of corneal collagen fibrils.
 
Keywords: 574 keratoconus  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×