June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
3T Magnetic Resonance Imaging of the Posterior Visual Pathway in Early and Advanced Human Primary Open Angle Glaucoma
Author Affiliations & Notes
  • Heather Connor
    Ophthalmology, University of Melbourne, Melbourne, VIC, Australia
  • Sarah Hosking
    Optometry and Vision Sciences, University of Melbourne, Melbourne, VIC, Australia
    Optometry and Visual Science, City University, London, United Kingdom
  • Jacques-Donald Tournier
    Brain Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, VIC, Australia
    Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia
  • David Abbott
    Brain Research Institute, Florey Institute of Neuroscience and Mental Health, Heidelberg, VIC, Australia
    Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia
  • Footnotes
    Commercial Relationships Heather Connor, None; Sarah Hosking, None; Jacques-Donald Tournier, None; David Abbott, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1708. doi:
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    • Get Citation

      Heather Connor, Sarah Hosking, Jacques-Donald Tournier, David Abbott; 3T Magnetic Resonance Imaging of the Posterior Visual Pathway in Early and Advanced Human Primary Open Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1708.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To determine the impact of primary open angle glaucoma (POAG) on structures of the posterior visual pathway using 3T Magnetic Resonance Imaging (MRI)

Methods: 57 normal controls (NC: mean age 58 (standard deviation) ± 12y, range 40 - 82y) and 37 POAG patients (mean age 66 ± 10y, range 44 - 87y) were included. Patients had repeatable visual field loss (Humphrey 24-2) or optic disc features consistent with the diagnosis of glaucoma. POAG patients were grouped as early (GLe) or advanced (GLa) using the AGIS grading system. MRI (3T Siemens Trio) T1, T2 and diffusion-weighted images were acquired and used to determine retrobulbar optic nerve diameter (ROND), optic radiations volume (ORV), fractional anisotropy (FA) mean diffusion (MD), radial diffusion (RD) (MRTrix software) and grey matter visual cortex volume (VCV: SPM8 software). ANCoVA was used to determine differences between groups using age and gender as covariants (SPSS20).

Results: Mean ROND 15mm behind the globe was significantly thinner in both GLe and GLa groups (NC 2.23mm ± 0.3; GLe 1.91mm ± 0.24: p=0.001; GLa 1.68 ± 0.45: p<0.001). ORV was reduced in GLa (3017.4 mm3 ± 517.9) compared to both NC (3426.1 mm3 ± 370.7: p=0.001) and GLe (3306.7 mm3 ± 301.7: p=0.048). FA was reduced in GLa (0.410 ± 0.023) compared to NC (0.448 ± 0.023: p<0.001) and GLe (0.439 ± 0.021: p<0.01) while RD was increased in GLa (459.34µm2/sec ± 45.72) compared to NC (417.78 µm2/sec ± 28.87: p<0.01) and GLe (528.20µm2/sec ± 22.54: p=0.05). There was no difference in VCV between groups.

Conclusions: Advanced glaucoma patients show reduced FA and increased RD in the optic radiations suggesting a loss of axonal integrity associated with glaucoma. ROND was thinner in early and advanced glaucoma patients although ORV was reduced only in the advanced group and there was no difference in VCV between any of the groups suggesting that changes in the posterior visual pathway associated with glaucoma lag anterior change.

Keywords: 550 imaging/image analysis: clinical • 629 optic nerve • 755 visual cortex  
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