June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Catechins attenuate sodium iodate-induced retinal degeneration
Author Affiliations & Notes
  • Yaping Yang
    Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Yongjie Qin
    Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Yolanda Yip
    Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Kai On Chu
    Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
    Department of Obstetrics & Gynaecology, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Kwok Ping Chan
    Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Chi Pui Pang
    Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Sun On Chan
    Department of School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong
  • Footnotes
    Commercial Relationships Yaping Yang, None; Yongjie Qin, None; Yolanda Yip, None; Kai On Chu, None; Kwok Ping Chan, None; Chi Pui Pang, None; Sun On Chan, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1799. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Yaping Yang, Yongjie Qin, Yolanda Yip, Kai On Chu, Kwok Ping Chan, Chi Pui Pang, Sun On Chan; Catechins attenuate sodium iodate-induced retinal degeneration. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1799.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: To investigate the biological effects of (-)-epigallocatechin gallate (EGCG), catechins combination {(-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG), (+)-gallocatechin (GC)}, catechins combination (GC, EGC, and EC), and green tea extract Theaphenon® E on sodium iodate-induced retinal degeneration in rats.

Methods: Adult Sprague-Dawley rats were injected intravenously with single dose of 40 mg/kg sodium iodate and administered intra-gastrically with EGCG, catechins combination (EGCG, GC, EGC, and EC), catechins combination (GC, EGC, and EC), and Theaphenon® E. Controls were injected i.v. with normal saline or 40 mg/kg sodium iodate. After in vivo examination of the retinas by confocal scanning laser ophthalmoscopy (CSLO) and spectral domain optical coherence tomography (SD-OCT), the rats were sacrificed for biochemical and histological analyses, including determination of Superoxide dismutase (SOD), glutathione peroxidase (GPx), caspase 3 mRNA, and 8-Iso-PGF2α concentration in the retina.

Results: CSLO revealed decrease in hyporeflective blots in the retina after treatment with EGCG, catechins combination (EGCG, GC, EGC, and EC), and Theaphenon® E. Concomitant protective effects of these catechins were observed in histological preparations with reduction retinal lesion. Expressions of SOD, GPx, caspase 3 and 8-Iso-PGF2α in the retina were reduced, indicating strong anti-oxidant effects of the catechins.

Conclusions: EGCG, catechins combination (EGCG, GC, EGC, and EC) and Theaphenon® E attenuated sodium iodate-induced retinal degeneration in rats, supporting the notion that catechins may alleviate oxidative stress in the retina.

Keywords: 688 retina  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×