June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Corneal sensitivity and morphology of the corneal subbasal nerve plexus in primary congenital glaucoma
Author Affiliations & Notes
  • Zisis Gatzioufas
    Dpt. of Ophthalmology, University Hospitals of Geneva HUG, Geneva, Switzerland
    Dpt. of Ophthalmology, Saarland University Medical Center UKS, Homburg/Saar, Germany
  • Farhad Hafezi
    Dpt. of Ophthalmology, University Hospitals of Geneva HUG, Geneva, Switzerland
  • Berthold Seitz
    Dpt. of Ophthalmology, Saarland University Medical Center UKS, Homburg/Saar, Germany
  • Footnotes
    Commercial Relationships Zisis Gatzioufas, None; Farhad Hafezi, Schwind (F), Ziemer (F), PCT/CH 2012/000090 (P); Berthold Seitz, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1876. doi:
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    • Get Citation

      Zisis Gatzioufas, Farhad Hafezi, Berthold Seitz; Corneal sensitivity and morphology of the corneal subbasal nerve plexus in primary congenital glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1876.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To quantify corneal subbasal nerve density and total number of nerve fibers in primary congenital glaucoma (PCG) and evaluate their impact on corneal sensitivity.

Methods: Forty eyes of 26 PCG patients were compared with 40 eyes randomly selected from 40 non-glaucoma patients who populated the control group. Central corneal sensitivity (CCS) was assessed by means of Cochet-Bonnet esthesiometry. Mean subbasal nerve density and total number of nerve fibers were quantified by laser-scanning confocal microscopy (LSCM). Normality of data was assessed by Kolmogorov-Smirnov testing. Differences in parameters were assessed with Student’s t test while correlations with CSS with Pearson’s correlation.

Results: Significant differences were identified in the mean subbasal nerve density (2108±692μm in PCG, 2642±484μm in controls, p= 0.003) and total number of nerve fibers (12.3±4.2 in PCG, 15.4±3.1 in controls, p= 0.02). Both groups presented comparable mean CCS and tortuosity. Both groups presented strong correlations between CCS and mean nerve density (r= 0.57 in PCG, r= 0.67 in controls, all p<0.05), and between CCS and total number of nerve fibers (r= 0.55 in PCG, r= 0.56 in controls, all p<0.05).

Conclusions: PCG exerts significant changes both in the mean subbasal nerve density and the total number of nerve fibers. However, these changes do not appear to affect central corneal sensitivity.

Keywords: 596 microscopy: confocal/tunneling  
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