June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Structure-Function Relationship between Spectral Domain Optical Coherence Tomography ,Heidelberg Retina Tomograph and Flicker Defined Form Perimetry in Patients with Ocular Hypertension and Preperimetric Glaucoma
Author Affiliations & Notes
  • Ermengarda Marziani
    Eye Clinic Department of Biomedical and Clinical Science "Luigi Sacco", Luigi Sacco Hospital, Milan, Italy
  • Laura de Polo
    Eye Clinic Department of Biomedical and Clinical Science "Luigi Sacco", Luigi Sacco Hospital, Milan, Italy
    COB, Centro Oculistico Bergamasco, Bergamo, Italy
  • Erma Collaku
    Eye Clinic Department of Biomedical and Clinical Science "Luigi Sacco", Luigi Sacco Hospital, Milan, Italy
  • Elena Weiszberger
    Eye Clinic Department of Biomedical and Clinical Science "Luigi Sacco", Luigi Sacco Hospital, Milan, Italy
  • Alessandra Acquistapace
    Eye Clinic Department of Biomedical and Clinical Science "Luigi Sacco", Luigi Sacco Hospital, Milan, Italy
  • Andrea Giani
    Eye Clinic Department of Biomedical and Clinical Science "Luigi Sacco", Luigi Sacco Hospital, Milan, Italy
  • Mirella Blini
    Eye Clinic Department of Biomedical and Clinical Science "Luigi Sacco", Luigi Sacco Hospital, Milan, Italy
  • Giovanni Staurenghi
    Eye Clinic Department of Biomedical and Clinical Science "Luigi Sacco", Luigi Sacco Hospital, Milan, Italy
  • Footnotes
    Commercial Relationships Ermengarda Marziani, None; Laura de Polo, None; Erma Collaku, None; Elena Weiszberger, None; Alessandra Acquistapace, None; Andrea Giani, Bayer (C), Novartis (R), Allergan (R); Mirella Blini, None; Giovanni Staurenghi, Ocular Instruments (P), GSK (C), Novartis (C), Alcon (C), Allergan (C), Bayer (C), Roche (C), Heidelberg Engineering (C), OD-OS (C), QLT (C), Optos (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1880. doi:
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      Ermengarda Marziani, Laura de Polo, Erma Collaku, Elena Weiszberger, Alessandra Acquistapace, Andrea Giani, Mirella Blini, Giovanni Staurenghi; Structure-Function Relationship between Spectral Domain Optical Coherence Tomography ,Heidelberg Retina Tomograph and Flicker Defined Form Perimetry in Patients with Ocular Hypertension and Preperimetric Glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1880.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To assess the correlation between Heidelberg edge perimetry (HEP) and peripapillary retinal nerve fiber layer (RNFL) thickness measured by spectral-domain optical coherence tomography (SD-OCT) Spectralis and by Heidelberg Retina Tomograph III (HRT-III), (Heidelberg Engineering, Heidelberg, Germany).

 
Methods
 

The study involved 60 eyes with ocular hypertension (OHT) and/or optic nerve suspicious for glaucoma without visual field damages detectable with the Standard Automated Perimetry (SAP). All eyes underwent RNFL imaging with Spectralis SD-OCT, topographic imaging HRT-III and Flicker Defined Form Perimetry with HEP. Cohen’s Kappa statistic (k) was used to assess the agreement between SD-OCT and HEP and between HRT and HEP for each of the six RNFL sectors.

 
Results
 

Between Spectralis SD-OCT and HEP agreement was fair (0.38) in the nasal sector, good (0.64-0.68) in the superior temporal and inferior temporal sectors and moderate (0.44-0.52) in the superior nasal, inferior nasal and temporal sectors. Between HRT and HEP agreement was slight (0.14-0.16) in the temporal and inferior temporal sectors, fair (0.24-0.34) in the other sectors.

 
Conclusions
 

The agreement between HEP and Spectralis SD-OCT was better than HEP and HRT. With Spectralis SD-OCT the strongest correlations were found in the superior and inferior temporal sectors as the ISN’T rule suggests for detecting preperimetric RNFL defects.

 
Keywords: 629 optic nerve • 642 perimetry • 610 nerve fiber layer  
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