June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
OPTIC NERVE AND LATERAL GENICULATE BODY IN GLAUCOMA AND ITS ASSOCIATION WITH FUNCTIONAL AN STRUCTURAL OCULAR ALTERATIONS
Author Affiliations & Notes
  • Augusto Paranhos
    Oftalm-Inst da Visao/EP, Federal Univ of Sao Paulo, Sao Paulo, Brazil
    Hospital Israelita Albert Einstein, Sao Paulo, Brazil
  • Rafael Furlanetto
    Oftalm-Inst da Visao/EP, Federal Univ of Sao Paulo, Sao Paulo, Brazil
  • Sergio Teixeira
    Oftalm-Inst da Visao/EP, Federal Univ of Sao Paulo, Sao Paulo, Brazil
    Hospital Israelita Albert Einstein, Sao Paulo, Brazil
  • Claudio Lottenberg
    Oftalm-Inst da Visao/EP, Federal Univ of Sao Paulo, Sao Paulo, Brazil
    Hospital Israelita Albert Einstein, Sao Paulo, Brazil
  • Daniela Almeida-Freitas
    Oftalm-Inst da Visao/EP, Federal Univ of Sao Paulo, Sao Paulo, Brazil
    Hospital Israelita Albert Einstein, Sao Paulo, Brazil
  • Edson Amaro
    Oftalm-Inst da Visao/EP, Federal Univ of Sao Paulo, Sao Paulo, Brazil
    Hospital Israelita Albert Einstein, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships Augusto Paranhos, Allergan (F), MSD (F); Rafael Furlanetto, None; Sergio Teixeira, None; Claudio Lottenberg, None; Daniela Almeida-Freitas, None; Edson Amaro, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1892. doi:
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    • Get Citation

      Augusto Paranhos, Rafael Furlanetto, Sergio Teixeira, Claudio Lottenberg, Daniela Almeida-Freitas, Edson Amaro; OPTIC NERVE AND LATERAL GENICULATE BODY IN GLAUCOMA AND ITS ASSOCIATION WITH FUNCTIONAL AN STRUCTURAL OCULAR ALTERATIONS. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1892.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To analyze the correlation between 3-Tesla high-speed magnetic resonance imaging (MR) findings of the intraorbital optic nerve and lateral geniculate body (LGB), and structural evaluation of the optic nerve head or visual function assessed by psychophysical tests in glaucomatous patients.

 
Methods
 

This was a cross-sectional prospective study including healthy volunteers and glaucoma patients. All participants performed SITA-standard 24-2 automated perimetry (SAP) and frequency doubling perimetry (FDT) (psychophysical tests), optic disc stereophotograph, spectral-domain optical coherence tomography (OCT), confocal scanning laser tomography (HRT), (structural evaluation) and MR. Anatomic-functional correlation was performed with Generalized Linear Models.

 
Results
 

41 glaucoma patients and 12 healthy volunteers were included and 56,86% was female. Mean age was 62,87±0,71 years in glaucoma group and 62,3±6,17 healthy group. There was a significant difference between the height of LGB in glaucoma group (mean: 0.38 mm) and in the control group (mean: 0.41 mm), p=0.005. No significant difference was found regarding base length and area of LGB between the two groups. Regarding orbital segment area of the optic nerve, a significant difference between the two groups was found 5mm from the globe (P=0.003) but not for 10 mm and 15 mm (P>0.05). LGB parameters were not significantly associated with any structural parameter tested (Average OCT RNFL thickness, HRT cup/disk ratio, stereo photo cup/disk ratio) as well as for any functional parameter (SAP MD, SAP VFI and FDT MD). Proximal (5mm) intraorbital optic nerve area was significant correlated with FDT MD (p=0.008) but with no other tested parameter.

 
Conclusions
 

Glaucoma patients presented a significant difference in height of LGB as well as a lower area of the proximal (5mm) intraorbital optic nerve segment. Functional and structural ocular parameters were not well associated with both intraorbital optic nerve segment areas or LGB parameters.

  
Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 755 visual cortex • 550 imaging/image analysis: clinical  
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