June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Extended Clinical Phenotype of Dome-Shaped Macula
Author Affiliations & Notes
  • Marie-Helene Errera
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology., London, United Kingdom
  • Michel Michaelides
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology., London, United Kingdom
  • Pearse Keane
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology., London, United Kingdom
  • Anthony Moore
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology., London, United Kingdom
  • Jonathan Yeoh
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology., London, United Kingdom
  • Derek Chan
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology., London, United Kingdom
  • Catherine Egan
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology., London, United Kingdom
  • Praveen Patel
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology., London, United Kingdom
  • Adnan Tufail
    NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology., London, United Kingdom
  • Footnotes
    Commercial Relationships Marie-Helene Errera, None; Michel Michaelides, Novartis (R); Pearse Keane, None; Anthony Moore, None; Jonathan Yeoh, None; Derek Chan, None; Catherine Egan, Bayer (S), Oculogics (S), Novartis (S), Allergan (S), Novartis (F); Praveen Patel, Allergan (R), Bayer (C), Novartis UK (C), Heidelberg UK (R), Topcon UK (R), Thrombogenics (C); Adnan Tufail, Allergan (C), Bayer (C), GSK (C), Oculogics (C), Pfizer (C), Thrombogenics (C), Amakem (C), Heidelberg Engineering (R), Novarits/Alcon (C), Sanofi/Genzyme (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 1908. doi:
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    • Get Citation

      Marie-Helene Errera, Michel Michaelides, Pearse Keane, Anthony Moore, Jonathan Yeoh, Derek Chan, Catherine Egan, Praveen Patel, Adnan Tufail; Extended Clinical Phenotype of Dome-Shaped Macula. Invest. Ophthalmol. Vis. Sci. 2013;54(15):1908.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To describe the phenotype, associations and complications of dome-shaped macula with the use of spectral domain optical coherence tomography (OCT) scan and B scan ultrasound.

Methods: Fifty-eight eyes of 36 patients were retrospectively identified as having OCT features of dome-shaped macula (DSM). All subjects had undergone enhanced depth imaging (EDI) OCT choroidal imaging as part of the scanning protocol. Fifteen patients underwent a B scan ultrasound to determine axial length and posterior coat thickness. Choroidal thickness and retinal thickness was determined with OCT, with scleral thickness subsequently calculated by subtraction from the ultrasound derived posterior coat thickness.

Results: Dome-shaped macula was associated with myopia (81 %). The underlying clinical diagnosis was variable, including: central serous chorioretinopathy (CSCR)-like entity (32.7%), chorioretinal neovascularization (CNV) (20.7%), and inherited retinal disorders (19%). The subfoveal choroidal thickness of the 9 highly myopic eyes with a CSCR-like phenotype (239 ± 144µm) was thicker than the 25 eyes without CSCR (153 ± 161µm) (p=0.169).

Conclusions: This study confirms the previous finding in highly myopic eyes with dome-macula of the presence of local scleral thickening and in addition the novel observation of a thickened choroid if CSCR is present. The observation of the thickened choroid may have therapeutic implications. We also expand the associations of dome-shaped macula to include eyes with hypermetropia and acquired disease, and also inherited retinal disease.

Keywords: 688 retina • 550 imaging/image analysis: clinical • 605 myopia  
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