June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Is Peripheral Retinal Ischemia Associated with Systemic Atherosclerosis?
Author Affiliations & Notes
  • Ashley Speilburg
    Illinois College of Optometry, Illinois Eye Institute, Chicago, IL
  • Shaun Ittiara
    Section of Ophthalmology and Visual Science, Department of Surgery, University of Chicago, Chicago, IL
  • Yi Pang
    Illinois College of Optometry, Illinois Eye Institute, Chicago, IL
  • Danielle Leong
    Illinois College of Optometry, Illinois Eye Institute, Chicago, IL
  • Ravi Patel
    Retinal Vitreal Consultants, Chicago, IL
  • Leonard Messner
    Illinois College of Optometry, Illinois Eye Institute, Chicago, IL
  • Seenu Hariprasad
    Section of Ophthalmology and Visual Science, Department of Surgery, University of Chicago, Chicago, IL
  • Footnotes
    Commercial Relationships Ashley Speilburg, None; Shaun Ittiara, None; Yi Pang, None; Danielle Leong, None; Ravi Patel, None; Leonard Messner, None; Seenu Hariprasad, Bayer (C), Regeneron (C), Regeneron (R), Alcon (C), Alcon (R), Allergan (C), Allergan (R), OD-OS (I), Optos (C), Ocular Therapeutix (I)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 194. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Ashley Speilburg, Shaun Ittiara, Yi Pang, Danielle Leong, Ravi Patel, Leonard Messner, Seenu Hariprasad; Is Peripheral Retinal Ischemia Associated with Systemic Atherosclerosis?. Invest. Ophthalmol. Vis. Sci. 2013;54(15):194.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: Previous studies have found that diabetic patients presenting with retinopathy have a higher intima media thickness (IMT) than diabetic patients without retinopathy and patients with severe diabetic retinopathy are more likely to have subclinical vascular disease. The purpose of this study was to investigate whether there was a correlation between peripheral retinal non-perfusion and IMT thickness of the common carotid artery in patients with diabetic retinopathy.

Methods: A total of 15 subjects with diabetic retinopathy were enrolled (age ranged from 26 to 78 years). Ultra-widefield fluorescein angiography images on both eyes and common carotid ultrasound scans of both carotid arteries were obtained. Using area measurement function in the V2 Vantage Review Software (Optos, PLC), one of the coauthors decided both the total area of gradable fundus and non-perfusion area seen in the arteriovenous phase of the ultra-widefield fluorescein angiogram. The ischemic index (ISI) was calculated by dividing the non-perfused retinal area with the total retinal area. Pearson correlation was performed to test the association between peripheral retinal non-perfusion and IMT thickness of the right and left carotid artery.

Results: Average (± SD) IMT in the right carotid artery was 0.870 (± 0.182) mm ranged from 0.52 to 1.24 mm, and 0.836 (± 0.213) in the left carotid artery ranged from 0.51 to 1.28 mm. Average ISI in the right eye was 0.145 (± 0.134) ranged from 0.10 to 0.40, and 0.144 (± 0.144) in the left eye ranged from 0.01 to 0.47. There was no correlation between ISI and IMT either in the right side (r = 0.08, P = 0.77) nor in the left side (r = 0.01, P = 0.97).

Conclusions: In this pilot study we were not able to determine a relationship between retinal ischemia and carotid atherosclerosis in patients with diabetic retinopathy. A limit of this study is the small sample size and further investigation with a larger cohort is indicated.

Keywords: 499 diabetic retinopathy • 688 retina  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×