June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
CICATRICIAL CHANGES IN OCULAR PEMPHIGUS
Author Affiliations & Notes
  • Patricia Chirinos-Saldaña
    Cornea and Refractive Surgery, Instituto de Oftalmología Conde de Valenciana, Mexico DF, Mexico
  • Isaac Zuñiga-Gonzalez
    Cornea and Refractive Surgery, Instituto de Oftalmología Conde de Valenciana, Mexico DF, Mexico
  • Julio Hernandez-Camarena
    Cornea and Refractive Surgery, Instituto de Oftalmología Conde de Valenciana, Mexico DF, Mexico
  • Alejandro Navas
    Cornea and Refractive Surgery, Instituto de Oftalmología Conde de Valenciana, Mexico DF, Mexico
  • Tito Ramirez-Luquín
    Cornea and Refractive Surgery, Instituto de Oftalmología Conde de Valenciana, Mexico DF, Mexico
  • Atzin Robles-Contreras
    Cornea and Refractive Surgery, Instituto de Oftalmología Conde de Valenciana, Mexico DF, Mexico
  • Maria Jimenez-Martinez
    Cornea and Refractive Surgery, Instituto de Oftalmología Conde de Valenciana, Mexico DF, Mexico
  • Arturo Ramirez-Miranda
    Cornea and Refractive Surgery, Instituto de Oftalmología Conde de Valenciana, Mexico DF, Mexico
  • Enrique Graue-Hernández
    Cornea and Refractive Surgery, Instituto de Oftalmología Conde de Valenciana, Mexico DF, Mexico
  • Footnotes
    Commercial Relationships Patricia Chirinos-Saldaña, None; Isaac Zuñiga-Gonzalez, None; Julio Hernandez-Camarena, None; Alejandro Navas, None; Tito Ramirez-Luquín, None; Atzin Robles-Contreras, None; Maria Jimenez-Martinez, None; Arturo Ramirez-Miranda, Carl Zeiss Meditec (R); Enrique Graue-Hernández, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2053. doi:
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    • Get Citation

      Patricia Chirinos-Saldaña, Isaac Zuñiga-Gonzalez, Julio Hernandez-Camarena, Alejandro Navas, Tito Ramirez-Luquín, Atzin Robles-Contreras, Maria Jimenez-Martinez, Arturo Ramirez-Miranda, Enrique Graue-Hernández; CICATRICIAL CHANGES IN OCULAR PEMPHIGUS. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2053.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To describe the ophthalmic clinical characteristics in patients with pemphigus at an ophthalmological referral center.

Methods: A retrospective chart review of patients with the immunopathological diagnosis of pemphigus examined between January 1, 2000, to April 1, 2010 was performed. Uncorrected distance visual acuity, best corrected distance visual acuity (BCVA), and ocular symptoms as well as ocular surface inflammatory and scarring changes were assessed.

Results: 15 patients were identified, with a mean age of 68.27 ± 14.35 years, and 80% (n = 12) were female. Extraocular involvement was reported in 1 patient. All eyes showed cicatricial changes in the conjunctiva. Six eyes (36.7%) were classified as stage I; 12 eyes (40%), as stage II; 10 eyes (33%), as stage III; and 2 eyes (7%), as stage IV. A statistically significant association was found between BCVA and the severity of ocular involvement. Mean BCVA logMAR was 1.66 (20/914), range from 0 (20/20) to 4 (NLP). Other ocular diseases were found in 8 (53.3%), systemic diseases in 10 (66.7%) and the use of pemphigus inducing drugs in 10 patients (66.7%).

Conclusions: This report represents the largest series of ocular involvement in pemphigus confirmed by immunopathology. The clinical manifestations varied from conjunctival hyperemia to corneal scarring and perforation. There was a strong association between scarring changes and low BCVA. Ocular and systemic diseases as well as the use of pemphigus inducing drugs may predispose to ocular cicatricial changes observed in this series.

Keywords: 479 cornea: clinical science • 554 immunohistochemistry • 474 conjunctiva  
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