June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Serum uric acid and newly developed diabetic retinopathy in type 2 diabetes mellitus-a 3 years’ prospective study
Author Affiliations & Notes
  • Shih-Hao Wang
    Ophthalmology, Kaohsiung Chamg Gung Memorial Hospital, Kaohsiung City, Taiwan
  • Jong-Jer Lee
    Ophthalmology, Kaohsiung Chamg Gung Memorial Hospital, Kaohsiung City, Taiwan
  • Hsi-Kung Kuo
    Ophthalmology, Kaohsiung Chamg Gung Memorial Hospital, Kaohsiung City, Taiwan
  • I-Hui Yang
    Ophthalmology, Kaohsiung Chamg Gung Memorial Hospital, Kaohsiung City, Taiwan
  • Footnotes
    Commercial Relationships Shih-Hao Wang, None; Jong-Jer Lee, None; Hsi-Kung Kuo, None; I-Hui Yang, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 207. doi:
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      Shih-Hao Wang, Jong-Jer Lee, Hsi-Kung Kuo, I-Hui Yang; Serum uric acid and newly developed diabetic retinopathy in type 2 diabetes mellitus-a 3 years’ prospective study. Invest. Ophthalmol. Vis. Sci. 2013;54(15):207.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

Hyperuricemia is a risk factor of diabetic nephropathy and cardiovascular mortality. The aim of this study was to explore the role of uric acid in diabetic retinopathy (DR) of type 2 diabetes mellitus (DM).

 
Methods
 

A prospective study of DR for 3 years was conducted on 776 type 2 diabetic patients in a medical center. Baseline serum uric acid (SUA) and parameters including glycemic control, blood pressure, and kidney function were collected for analyzing their contribution to the evolution of DR during the period of study.

 
Results
 

Fundus examination showed 528 patients (68.0%) had no DR at baseline. After 3 years, newly developed DR was recognized in 84 (15.9%). The concentration of SUA in patients of our study ranged from 1.60-11.2 mg/dl. We found that the ratio of newly developed DR was significantly higher (p < 0.001) for patients in the fourth (serum uric acid ≥ 7.1 mg/dl) when compared with patients in the first quartile (serum uric acid < 4.8 mg/dl). Patients with newly developed DR had a higher concentration of SUA (6.6±1.7 vs. 5.9±1.5, p < 0.001) than others without DR at the end of study. SUA was an independent factor associated with newly developed (p=0.002; 95% C.I. 1.12-1.64) DR after adjust for demographic and traditional risk factors including HbA1c, hypertension, and impaired kidney function.

 
Conclusions
 

High serum uric acid preceded both the newly developed DR in 3 years. The finding provides the evidence for monitoring the serum uric acid level in type 2 diabetic patients.

 
Keywords: 499 diabetic retinopathy • 464 clinical (human) or epidemiologic studies: risk factor assessment  
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