June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Subconjunctival Cyclosporine A implants do not affect corneal neovascularisation after transplantation: results of a randomized clinical trial
Author Affiliations & Notes
  • Claus Cursiefen
    Dept of Ophthalmology, University of Cologne, Koln, Germany
  • Thomas Reinhard
    Dept. of Ophthalmology, University of Freiburg, Freiburg, Germany
  • Felix Bock
    Dept of Ophthalmology, University of Cologne, Koln, Germany
  • Hans-Ulrich Prokosch
    Medical Informatics, University of Erlangen, Erlangen, Germany
  • Footnotes
    Commercial Relationships Claus Cursiefen, Gene Signal (C), Alcon (R), Allergan (R), Bayer (R); Thomas Reinhard, None; Felix Bock, None; Hans-Ulrich Prokosch, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2090. doi:
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    • Get Citation

      Claus Cursiefen, Thomas Reinhard, Felix Bock, Hans-Ulrich Prokosch; Subconjunctival Cyclosporine A implants do not affect corneal neovascularisation after transplantation: results of a randomized clinical trial. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2090.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To test whether subconjunctivally implanted Cyclosporine A affects the incidence and degree of postkeratoplasty corneal neovascularisation.

Methods: Prospective, randomized, controlled phase II/III clinical trial comprising trial sites in Germany, India and the USA. Overall, 97 enrolled patients were randomized to receive either two dosages of subconjunctival Cyclosporine A implants (A: 36 and B: 40) or placebo (n=21) at time of penetrating keratoplasty. The incidence and degree of postkeratoplasty corneal neovascularisation were evaluated (LX201-01 study). A web-based image upload system was developed. Quantitative and objetive evaluation of standardized digital slit lamp pictures was performed using AnlysisB morphometry sofware.

Results: No significant difference in the incidence and the degree of corneal neovascularisation was found between treatment groups and placebo group. Mean neovascularisation was 3.2% ± 0.3 in treatment A versus placebo (3.5% ± 0.27; p= 0.5) and 3.0% ± 0.4 and in treatment B versus placebo (3.5% ± 0.27; p= 0.3).

Conclusions: Subconjunctival cyclosporine A does not affect postkeratoplasty corneal neovascularisation.

Keywords: 609 neovascularization • 479 cornea: clinical science • 741 transplantation  
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