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Woo Park, Jeong Bum Bae, Won Yeol Ryu; Histologic characteristics of conjunctivochalasis and its correlation with lymphangiectasis. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2118.
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To evaluate the histologic characteristics of conjunctivochalasis and its association with lymphangiectasis using impression cytology and biopsy.
A prospective study was included in 14 conjunctivochalasis patient who was performed excisional biopsy from Mar. to Nov. 2012. Dry eye evaluation test and impression cytology were performed. Histologic evaluation was done with H&E, Verhoeff Van Gieson and D2-40 immuno stain using excised conjunctiva.
Tear break-up time and Schirmer’s value was decreased. Impression cytology showed the decrease in goblet cell density and an increase in nucleoplasmic/cytoplasmic ratio. Conjunctiva from conjunctivochalasis patients showed increase in infiltration of chronic inflammatory cells on H&E stain, and decrease in collagen density with degeneration of elastic fibers on Verhoeff Van Gieson stain, and D2-40 immunohistochemistry showed the dilation of subconjunctival lymphatics compared to those from the control.
Conjunctivochalais is associated with lymphangiectasis and decrease of goblet cells density.
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