June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Cysteinyl leukotriene receptors expression in the giant papillae of the chronic allergic conjunctivitis
Author Affiliations & Notes
  • Kaori Ohtomo
    Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
  • Nobuyuki Ebihara
    Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
  • Norihiko Yokoi
    Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Satoshi Kawasaki
    Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Akira Murakami
    Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
  • Akira Matsuda
    Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan
  • Footnotes
    Commercial Relationships Kaori Ohtomo, None; Nobuyuki Ebihara, None; Norihiko Yokoi, Santen Pharmaceutical (F), Otsuka Pharmaceutical (F), Kowa (P), Kissei Pharmaceutical (C), Menicon (F), Alcon Japan (F), White medical (F), Nitten (F), Rohto (C), Nidek (F), Johson & Johnson (F); Satoshi Kawasaki, None; Akira Murakami, SEED(Japan) JP4855782 (P), SEED(Japan) JP5132958 (P); Akira Matsuda, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2119. doi:
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      Kaori Ohtomo, Nobuyuki Ebihara, Norihiko Yokoi, Satoshi Kawasaki, Akira Murakami, Akira Matsuda; Cysteinyl leukotriene receptors expression in the giant papillae of the chronic allergic conjunctivitis. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2119.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: The cysteinyl leukotrienes (LTC4, LTD3, and LTE4) have many biological effects, which augment allergic inflammation. Clinically, cysteinyl leukotriene receptor antagonists are widely used for the treatment of asthma and nasal allergy. To clarify the roles of cysteinyl leukotrienes signals in severe chronic allergic conjunctivitis, we investigated the expression of cysteinyl leukotriene receptors (CysLTR) in the resected giant papillae.

Methods: Anti-CysLTR1, CysLTR2, MBP, CD68, neutrophil elastases and tryptase immnunohistochemical staining were performed with the resected giant papillae obtained from AKC/VKC patients (n=9). Realtime PCR analysis was carried out to examine CysLTR1 mRNA expression in giant papillae obtained from VKC patients and control conjunctival tissue.

Results: CysLTR1 positive infiltrating cells were observed in the epithelium and substantia propria of the giant papillae. CysLTR1/neutrophil elastase double positive cells were localized in the substantia propria of the giant papillae. CysLTR2 positive vascular endothelial cells and CysLTR2/CD68 double positive cells were present in the giant papillae. CysLTR1 mRNA was detected in VKC patients.

Conclusions: CysLTR1 and CysLTR2 expression were observed in the giant papillae obtained from AKC/VKC patients.

Keywords: 475 conjunctivitis • 557 inflammation • 474 conjunctiva  
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