June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Squamous Metaplasia May Persist after Pterygium Excision and Limbal-Conjunctival Autograft
Author Affiliations & Notes
  • Soo Jeong Ryu
    Ophthalmology, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea
  • Sang Beom Han
    Ophthalmology, Samsung Medical Center, 81 Irwon-ro Gangnam-gu, Seoul, Republic of Korea
  • Hee Kyung Yang
    Ophthalmology, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea
  • Won Ryang Wee
    Ophthalmology, Seoul National University Hospital, 101 Daehak-ro Jongno-gu, Seoul 110-744, Republic of Korea
  • Joon Young Hyon
    Ophthalmology, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea
  • Footnotes
    Commercial Relationships Soo Jeong Ryu, None; Sang Beom Han, None; Hee Kyung Yang, None; Won Ryang Wee, None; Joon Young Hyon, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2126. doi:
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      Soo Jeong Ryu, Sang Beom Han, Hee Kyung Yang, Won Ryang Wee, Joon Young Hyon; Squamous Metaplasia May Persist after Pterygium Excision and Limbal-Conjunctival Autograft. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2126.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To investigate the changes of conjunctival epithelium at the pterygium and donor graft sites after pterygium excision and limbal-conjunctival autograft.

Methods: This is a prospective study that included 16 eyes of 15 patients. Impression cytology specimens were obtained preoperatively and at 1, 3 and 6 months postoperatively, at the site of the pterygium and donor graft site, respectively. In each specimen, changes of conjunctival epithelium were evaluated using the nucleus-to-cytoplasm(N/C) ratio and goblet cell density (GCD). Morphologic changes of cell and nucleus were also evaluated.

Results: Preoperatively, Both N/C ratio and GCD were significantly higher in specimens from pterygium site than those from graft harvest site. At both sites, GCD decreased rapidly at 1 month after surgery, but showed gradual recovery. No significant difference in GCD was found between the two sites at postoperative 1, 3 and 6 months. Although there was no significant difference in the N/C ratio at 1 and 3 month, pterygium site showed significantly higher N/C ratio than donor graft site at 6 months. At postoperative 6 months, changes suggesting squamous metaplasia elongation of the cells and pyknotic changes in the nuclei-was noticed in 5 samples from the pterygium site, although these changes were never found at donor graft site.

Conclusions: Conjunctival epithelial metaplasia may persist even after pterygium removal and limbal reconstruction. Restoration of limbal barrier function may prevent the corneal involvement of the metaplastic conjunctival epithelial cells.

Keywords: 665 pterygium  
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