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Sumihiro Kawano, Toshifumi Yamashita, Yasushi Sonoda, Keita Yamakiri, Taiji Sakamoto; Post-operative hemorrhage after vitrectomy for proliferative diabetic retinopathy with or without pre-surgical intravitreal bevacizumab. Invest. Ophthalmol. Vis. Sci. 2013;54(15):216.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effect of pre-surgical intravitreal bevacizumab (IVB) on vitrectomy for proliferative diabetic retinopathy (PDR).
IVB was done for PDR eyes (12 consecutive eyes, IVB group) within one week prior to vitrectomy. Those received vitrectomy for PDR without IVB were used as a control (15 eyes, control group). Baseline characteristics of two groups, visual outcome, post-operative hemorrhage were investigated.
There were no significant difference in the rate of increase of intraocular pressure (IVB group vs control group: 5 eyes VS 6 eyes, P=0.93), macular edema (IVB group vs control group: 11 eyes VS 13 eyes, P=0.69) and visual outcome (pre-operative logMAR: 1.46 VS 1.13 P=0.18, post-operative logMAR: 0.44 VS 0.52 P=0.62) between groups. Frequency of post-operative hemorrhage after 1 months were 4 times/15eyes, in IVB group and 0 times/12eyes in control group (P=0.057). No adverse events related to IVB such as stroke, hypertension, or unknown visual loss were observed during the observation.
Although the statistics did not reach significance, there was a tendency that pre-surgical IVB would decrease the incidence of hemorrhage after vitrectomy for PDR.
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