June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Glaucoma Severity Correlates with Lamina Cribrosa Depth and Thickness
Author Affiliations & Notes
  • Martha Kim
    Ophthalmology, University of Washington School of Medicine, Seattle, WA
  • Karine Bojikian
    Ophthalmology, University of Washington School of Medicine, Seattle, WA
  • Deana Choi
    Ophthalmology, University of Washington School of Medicine, Seattle, WA
  • Mark Slabaugh
    Ophthalmology, University of Washington School of Medicine, Seattle, WA
  • Philip Chen
    Ophthalmology, University of Washington School of Medicine, Seattle, WA
  • Footnotes
    Commercial Relationships Martha Kim, None; Karine Bojikian, None; Deana Choi, None; Mark Slabaugh, None; Philip Chen, Allergan (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2253. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to Subscribers Only
      Sign In or Create an Account ×
    • Get Citation

      Martha Kim, Karine Bojikian, Deana Choi, Mark Slabaugh, Philip Chen; Glaucoma Severity Correlates with Lamina Cribrosa Depth and Thickness. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2253.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: To evaluate the correlation between the lamina cribrosa (LC) morphology and glaucoma severity using enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT) and Humphrey visual field test (HVF).

Methods: Optic nerve head B-scans of 103 glaucoma patients were obtained using EDI SD-OCT. Images were analyzed using the Heidelberg Eye Explorer software. LC depth was defined as the greatest distance between the reference plane (the imaginary extension of Bruch’s membrane plane) and the anterior border of LC, perpendicular to the reference plane. LC thickness was the distance from anterior border to the posterior border of LC in the center of optic nerve head images of horizontal plane. The two global indices, mean deviation (MD) and pattern standard deviation (PSD) were obtained from HVF.

Results: The mean (± standard deviation) values of MD and PSD were -5.4 ± 5.8 dB and 6.2 ± 3.8 dB. The LC depth and the LC thickness were 540.26 ± 140.39 μm and 173.23 ± 50.02 μm. The LC depth showed weak but significant correlation with MD by Pearson correlation test and linear regression analysis (Pearson σ = -0.348; P < 0.001; r2 = 0.121; P < 0.001). The LC thickness also correlated with MD (Pearson σ = 0.337; P = 0.001; r2 = 0.114; P = 0.001). The PSD showed a similar correlation with the LC depth and the LC thickness. The intraclass correlation coefficients of two observers on performing measurements of the LC depth and the LC thickness showed high reproducibility (0.972 and 0.779).

Conclusions: Glaucoma severity shows a significant correlation with the LC depth and the LC thickness. These measures may be useful in optic nerve head analysis using SD-OCT.

Keywords: 577 lamina cribrosa • 629 optic nerve • 758 visual fields  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×