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Kazuhide Kawase, Hiroko Inuzuka, Tetsuya Yamamoto; An optical coherence tomographic study of macular ganglion cell layer and inner plexiform layer, and circumpapillary retinal nerve fiber layer in 2 years after a diagnosis of preperimetric glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2266.
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© ARVO (1962-2015); The Authors (2016-present)
To elucidate changes of the thickness of macular ganglion cell layer and inner plexiform layer (mGCIPL) and circumpapillary retinal nerve fiber layer (cpRNFL) measured by SD-OCT in 2 years after a diagnosis of preperimetric glaucoma (PPG) in a retrospective manner.
The PPG was defined as follows: an optic disc with neuroretinal rim thinning, cupping, or a suspicious RNFL defect, absence of visual field defects fulfilling the Anderson’s criteria and a refractive error less than 6D. One hundred twenty-one eyes of 121 patients with PPG were subjected. Mean deviation (MD) value from HFA C30-2 program, the mGCIPL thickness and the cpRNFL thickness from SD-OCT (Cirrus HD-OCT 4000) programs Ganglion Cell Analysis, Macula Cube 200x200 and Optic Disc Cube 200x200 at the time of diagnosed PPG and 2 years thereafter were reviewed.
We observed significant decrease of the mGCIPL thickness in all sectors (p<0.0001), but no significant decrease in MD value during the 2-year follow-up. We also observed significant decrease in the cpRNFL thickness in the superior, inferior, and temporal sectors (p<0.0001, p<0.0001, and p=0.0174, respectively).
The structural changes were recognized in the macula and circumpapillary retinal nerve fiber in two years after a diagnosis of PPG. SD-OCT is able to detect macular and circumpapillary retinal thinning in two years in PPG patients.
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