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Manuele Michelessi, Marco Centofanti, Francesco Oddone, Lucia Tanga, Danilo Iannetta, Pasquale Pasculli, Manuela Ferrazza, Gianluca Manni; Retinal nerve fiber layer and posterior pole asymmetry analysis by spectral domain-OCT: structure function relationship with visual field sensitivity in glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2275.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the structure function relationship between visual field (VF) sensitivity by standard automated perimetry (SAP) and retinal nerve fiber layer(RNFL) and macular thickness measured by spectral domain optical coherence tomography (SD-OCT), in glaucomatous patients.
Seventy-nine eyes of 79 consecutive glaucoma patients were enrolled. All subjects underwent a full eye examination, a SAP test (Humphrey field analyzer, 24-2 SITA standard) and were imaged with Spectralis SD-OCT (Heidelberg Engineering), at the same visit. RNFL scanning protocol and posterior pole asymmetry analysis were performed to obtain peripapillary RNFL and macular thickness, respectively. Abnormal visual field result (defined as PSD and MD p<5% and GHT outside normal limits) was used as reference standard. For the RNFL thickness data, six sectors were used to assess the structure function relationship with the VF matching areas. For the macular thickness data, we divided the 64 squares covering the posterior pole area resulting from the scan, in five sectors and we evaluate the relationship with corresponding VF matching area. The global as well as the hemifield data were also used and compared. The VF sensitivity was registered in the dB and 1/L scales and a linear regression analysis using the “least squares” method was used to measure the coefficient of determination(R2).
For the RNFL/VF relationship, the coefficient of determination(R2) ranged from 0,09 (nasal VF sector, db scales) to 0,53 (inferotemporal VF sector, 1/L scale). For the posterior pole/VF relationship, the coefficient of determination ranged from 0,17 (inferonasal VF sector, db scales) to 0,42 (inferotemporal VF sector, 1/L scale).
Structure function relationship between RNFL thickness and VF sensitivity was moderate and similar to that between posterior pole thickness and VF sensitivity. Infero temporal VF sector have shown the stronger association with structural corresponding area.
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