June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Correlation between peripapillary retinal nerve fiber layer thickness and visual field defect in glaucoma
Author Affiliations & Notes
  • Andre Luiz Silva
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • Luiz Alberto Melo
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • Moacyr Campos
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • Ivan Tavares
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships Andre Luiz Silva, None; Luiz Alberto Melo, None; Moacyr Campos, None; Ivan Tavares, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2283. doi:
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      Andre Luiz Silva, Luiz Alberto Melo, Moacyr Campos, Ivan Tavares; Correlation between peripapillary retinal nerve fiber layer thickness and visual field defect in glaucoma. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2283.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate the correlation between peripapillary retinal nerve fiber layer (RNFL) thickness and visual field indices using different spectral-domain optical coherence tomographies (SD-OCT) and visual field perimeters in glaucoma.

 
Methods
 

A cross-sectional study was carried out. Primary open-angle glaucoma patients were examined using Spectralis SD-OCT (Heidelberg Engineering, Heidelberg, Germany), Cirrus SD-OCT (Carl Zeiss Meditec, Dublin, CA), RTVue SD-OCT (Optovue, Inc., Freemont, CA), standard automated perimetry (24-2 SITA Standard test, Humphrey Field Analyzer 750, Carl Zeiss Meditec, Dublin, CA), and Frequency Doubling Technology Perimetry (24-2 test, FDT Matrix, Carl Zeiss Meditec, Dublin, CA). The correlation between mean peripapillary RNFL thickness and visual fields indices was analyzed using Spearman rank correlation test.

 
Results
 

A total of 44 eyes of 25 patients were included in the study. The mean (standard deviation) peripapillary RNFL thickness obtained by Spectralis, Cirrus, and RTVue were 74.7 (15.9) µm, 72.4 (12.5) µm, and 93.7 (17.4) µm, respectively. The mean (standard deviation) standard automated perimetry Mean Deviation (MD) index was -6.61 (7.12) dB. The RNFL thickness obtained by Spectralis and Cirrus showed similar, moderate correlations with visual field indices (Table). The correlation between RNFL thickness obtained by RTVue and visual field indices were weaker than those obtained by Spectralis and Cirrus OCT (Table).

 
Conclusions
 

Moderate correlations between peripapillary RNFL thickness and visual field indices were found in glaucoma patients. The correlation between RNFL thickness obtained by RTVue and visual field indices were weaker than those obtained by Spectralis and Cirrus OCT.

  
Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 642 perimetry • 610 nerve fiber layer  
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