June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Relationship between the mean deviation of the visuald field (Humphrey) and the analysis of the retinal fiber layer thickness of the optical coherence tomography (Stratus OCT) for moderates and severes glaucomatous eyes
Author Affiliations & Notes
  • Idriss Badat
    Service d'ophtalmologie, CHU La Milétrie, Poitiers, France
  • Edouard Dumas de La Roque
    Service d'ophtalmologie, CHU La Milétrie, Poitiers, France
  • Martial Mercie
    Service d'ophtalmologie, CHU La Milétrie, Poitiers, France
  • Benedicte Tougeron
    Service d'ophtalmologie, CHU La Milétrie, Poitiers, France
  • Nasser Yani
    Service d'ophtalmologie, CHU La Milétrie, Poitiers, France
  • Nadia Bouamama
    Service d'ophtalmologie, CHU La Milétrie, Poitiers, France
  • Julie Morin
    Département d4ophtalmologie, Hopital Rosemond-Maisonneuve, Montréal, QC, Canada
  • Pierre Ingrand
    Service d'ophtalmologie, CHU La Milétrie, Poitiers, France
  • Michèle Boissonnot
    Service d'ophtalmologie, CHU La Milétrie, Poitiers, France
  • Nicolas Leveziel
    Service d'ophtalmologie, CHU La Milétrie, Poitiers, France
  • Footnotes
    Commercial Relationships Idriss Badat, None; Edouard Dumas de La Roque, None; Martial Mercie, None; Benedicte Tougeron, None; Nasser Yani, None; Nadia Bouamama, None; Julie Morin, None; Pierre Ingrand, None; Michèle Boissonnot, None; Nicolas Leveziel, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2284. doi:
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      Idriss Badat, Edouard Dumas de La Roque, Martial Mercie, Benedicte Tougeron, Nasser Yani, Nadia Bouamama, Julie Morin, Pierre Ingrand, Michèle Boissonnot, Nicolas Leveziel; Relationship between the mean deviation of the visuald field (Humphrey) and the analysis of the retinal fiber layer thickness of the optical coherence tomography (Stratus OCT) for moderates and severes glaucomatous eyes. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2284.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate the capacity of optical coherence tomography Stratus (OCT) and its role in discriminating moderate versus severe glaucoma by the study of retinal nerve fiber layer thickness.

Methods: This comparative study includes sixty-six glaucomatous eyes (42 moderates and 24 severes). Eyes were separated in two groups according to Hoddap classification, based on the visual field white-white SITA Standard (Swedish Interactive Threshold Algorithms) 24.2. The peri-papillar retinal nerve fiber layer thickness was measured by the stratus OCT using the the protocol Fast RFNL Thickness. The studied Oct parameters used were the global average thickness (global mean), and the thickness of the retinal fiber layers on the four meridian lines. The OCT parameters were then compared with the mean deviation (MD) of the visual field.

Results: The global average thickness of the retinal nerve fiber layer is respectively 64.73 µm +/- 9.87, 54.14 +/- 9,98 for the moderate and the severe glaucomatous eyes with a significant difference of p=0.0007. The thickness of the retinal fiber layers on the four meridian quadrants were found significantly different between the two groups (p=0.05) for the temporal, superior and inferior meridian. The global mean and the inferior and temporal meridian lines showed the most important areas under the ROC curve (respectively 0.766 0.785 and 0.780) for the moderate glaucoma against the severe ones. The threshold of 44µm for the temporal quadrant has an ability of discrimination of 76% of specificity and sensibility.

Conclusions: OCT of optic nerve fiber layer is a very interesting discrimination tool for moderate to severe glaucoma. It gives estimation of nerve fiber layer thickness at which the disease risks to progress to a more severe stage. It complements well the visual field and combined to it, helps to the evaluation of the severity of glaucoma and its management even for advanced cases.

Keywords: 642 perimetry • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 627 optic disc  
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