June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Diagnostic power of the new colorimetry photographic device (Laguna ONhE) in glaucomatous and hypertensive eyes: comparative study with Spectralis optical coherence tomography and HRT III confocal tomography
Author Affiliations & Notes
  • Ignacio Rodriguez-Uña
    Glaucoma, Instituto de Investigación Sanitaria San Carlos (IdISSC) Fundación de Investigación Biomédica del Hospital Clínico San Carlos, Madrid, Spain
  • Carmen Mendez-Hernandez
    Glaucoma, Instituto de Investigación Sanitaria San Carlos (IdISSC) Fundación de Investigación Biomédica del Hospital Clínico San Carlos, Madrid, Spain
  • Manuel González-de-la-Rosa
    Hospital Universitario de Canarias, La Laguna, Spain
  • Federico Saenz-Frances
    Glaucoma, Instituto de Investigación Sanitaria San Carlos (IdISSC) Fundación de Investigación Biomédica del Hospital Clínico San Carlos, Madrid, Spain
  • Paula Arribas Pardo
    Glaucoma, Instituto de Investigación Sanitaria San Carlos (IdISSC) Fundación de Investigación Biomédica del Hospital Clínico San Carlos, Madrid, Spain
  • Jose Martinez de la Casa
    Glaucoma, Instituto de Investigación Sanitaria San Carlos (IdISSC) Fundación de Investigación Biomédica del Hospital Clínico San Carlos, Madrid, Spain
  • Julian Garcia-Feijoo
    Glaucoma, Instituto de Investigación Sanitaria San Carlos (IdISSC) Fundación de Investigación Biomédica del Hospital Clínico San Carlos, Madrid, Spain
  • Footnotes
    Commercial Relationships Ignacio Rodriguez-Uña, None; Carmen Mendez-Hernandez, None; Manuel González-de-la-Rosa, Haag Streit (P), Oculus (P); Federico Saenz-Frances, None; Paula Arribas Pardo, None; Jose Martinez de la Casa, None; Julian Garcia-Feijoo, Trancend (C), Ivantis (C), Glaukos (C), MSD (C), Allergan (F), Pfizer (F), Alcon (C), Sensimed (F), Sylentis (F), Bausch and Lomb (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2298. doi:
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      Ignacio Rodriguez-Uña, Carmen Mendez-Hernandez, Manuel González-de-la-Rosa, Federico Saenz-Frances, Paula Arribas Pardo, Jose Martinez de la Casa, Julian Garcia-Feijoo, ; Diagnostic power of the new colorimetry photographic device (Laguna ONhE) in glaucomatous and hypertensive eyes: comparative study with Spectralis optical coherence tomography and HRT III confocal tomography. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2298.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

Assessing the diagnostic power of the new device, Laguna ONhE, in the measurements of Optic Nerve Head Hemoglobin (ONHH) versus Spectralis optical coherence tomography (OCT) and confocal tomography (HRT III) in hypertensive and glaucomatous eyes.

 
Methods
 

Hypertensive (n=36), glaucomatous (n=66) and healthy (n=65) eyes were evaluated using Spectralis OCT, HRT III and non-mydriatic retinography of the Optic Nerve Head (ONH). ONHH was measured using Laguna ONhE software. Areas under ROC curve were calculated and correlation between those parameters with greater diagnostic power was investigated with Spearman Rho coefficient.

 
Results
 

The area under ROC curve for Glaucoma Discriminant Function (GDF) index calculated with Laguna ONhE was 0.756 (95% CI: 0.674-0.838). With OCT, the area for retinal nerve fiber layer thickness (RNFLT) was 0.741 (95% CI: 0.654-0.828). With HRT, two parameters were studied: Glaucoma Probability Score (GPS) and vertical cup-disc ratio. The values for the area under the curve were 0.742 (95% CI: 0.656-0.828) and 0.738 (95% CI: 0.652-0.824), respectively. GDF showed the best correlation with GPS of the HRT (-0.609, p<0.01), higher in severe glaucomatous eyes (-0.675) than in early (-0.519) or moderate (-0.450) glaucomatous eyes. GDF correlation with the RNFLT determined by OCT was 0,446 (p<0.01), all glaucomatous eyes considered.

 
Conclusions
 

ONHH concentration correlates with Spectralis OCT and HRT III parameters, with similar diagnostic power. The new colorimetry photographic device, Laguna ONhE, might be useful in structural diagnosis of glaucoma.

 
Keywords: 549 image processing • 610 nerve fiber layer • 628 optic flow  
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