June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Biopsy-Proven Giant Cell Arteritis in an Urban African American Population: a Hematologic and Demographic Profile
Author Affiliations & Notes
  • Matthew Katz
    Ophthalmology, Montefiore Medical Center - Albert Einstein College of Medicine, Bronx, NY
  • Barrett Katz
    Ophthalmology, Montefiore Medical Center - Albert Einstein College of Medicine, Bronx, NY
    Neurology and Neurosurgery, Montefiore Medical Center - Albert Einstein College of Medicine, Bronx, NY
  • Footnotes
    Commercial Relationships Matthew Katz, None; Barrett Katz, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2354. doi:
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      Matthew Katz, Barrett Katz; Biopsy-Proven Giant Cell Arteritis in an Urban African American Population: a Hematologic and Demographic Profile. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2354.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To delineate the serologic and demographic features of biopsy-proven giant cell arteritis (GCA) in an African American population.

 
Methods
 

A retrospective case series was assembled utilizing Clinical Looking Glass - software developed at Montefiore Medical Center - which integrates all clinical and demographic data of every patient and every clinical encounter. Records of every patient undergoing temporal artery biopsy between 2000 and 2011 were reviewed to identify those self-identified as African-Americans and for whom biopsy histologically confirmed the presence of giant cell arteritis. Thirteen such subjects were identified. Outcome measures were age at diagnosis, gender, and the highest measured result of three hematologic markers - (1) erythrocyte sedimentation rate (ESR); (2) C-reactive protein (CRP); and (3) thrombocyte levels - performed within three weeks of biopsy.

 
Results
 

The mean age of our cohort was 75.2 years, with a range of 62-85 years. 4/13 (30.8%) were male, and 9/13 (69.2%) female. 11/13 had ESR documented, with a mean value of 68 mm/hr (nl < 21) with a range 5-199 mm/hr. Of 8 subjects with measured CRP, mean value was 4.5 mg/dL (nl <0.9) with a range of 0.2-12.3 mg/dL. 12/13 had platelet determinations with a mean of 346 k/uL (nl 150-400) and range of 228-615 k/uL.

 
Conclusions
 

GCA - a systemic vasculitis characterized by involvement of large and medium-sized arteries and potential blinding sequelae- is still commonly considered a disease of a white population. Our series, among the largest to date, speaks to the contrary. This cohort demonstrates that GCA occurs in African-Americans, and its hematologic and demographic signatures are not dissimilar from those of whites. We conclude that the diagnosis of GCA ought be pursued as vigorously in patients of African-American descent as in persons of European origin, given the appropriate clinical setting.

 
Keywords: 613 neuro-ophthalmology: optic nerve • 612 neuro-ophthalmology: diagnosis • 629 optic nerve  
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