June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Prevalence of Structural Abnormalities of the Retinal Nerve Fiber Layer (RNFL) and Ganglion Cell Layer Complex (GCLC) by OCT in Veterans with Traumatic Brain Injury (TBI)
Author Affiliations & Notes
  • Randy Kardon
    Center of Excellence for the Prevention and Treatment of Visual Loss, Department of Veterans Affairs, Rehabilitation Research and Development Division, Iowa City, IA
    Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA
  • Mona Garvin
    Center of Excellence for the Prevention and Treatment of Visual Loss, Department of Veterans Affairs, Rehabilitation Research and Development Division, Iowa City, IA
    Electrical and Computer Engineering, University of Iowa, Iowa City, IA
  • Jui-Kai Wang
    Center of Excellence for the Prevention and Treatment of Visual Loss, Department of Veterans Affairs, Rehabilitation Research and Development Division, Iowa City, IA
    Electrical and Computer Engineering, University of Iowa, Iowa City, IA
  • Kimberly Cockerham
    Ophthalmology, Department of Veterans Affairs, Palo Alto, CA
  • Susan Anderson
    Center of Excellence for the Prevention and Treatment of Visual Loss, Department of Veterans Affairs, Rehabilitation Research and Development Division, Iowa City, IA
    Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA
  • Jan Full
    Center of Excellence for the Prevention and Treatment of Visual Loss, Department of Veterans Affairs, Rehabilitation Research and Development Division, Iowa City, IA
    Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA
  • Sonne Lemke
    Ophthalmology, Department of Veterans Affairs, Palo Alto, CA
  • Glenn Cockerham
    Ophthalmology, Department of Veterans Affairs, Palo Alto, CA
  • Footnotes
    Commercial Relationships Randy Kardon, Novartis (C), Acorda (C), Fight for Sight Inc (S), Department of Veterans Affairs Research Foundation Iowa City, IA (S); Mona Garvin, Patent application 12/001,066 (P); Jui-Kai Wang, None; Kimberly Cockerham, None; Susan Anderson, None; Jan Full, None; Sonne Lemke, None; Glenn Cockerham, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2360. doi:
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      Randy Kardon, Mona Garvin, Jui-Kai Wang, Kimberly Cockerham, Susan Anderson, Jan Full, Sonne Lemke, Glenn Cockerham, Iowa City VA RR&D Center of Excellence for the Prevention and Treatment of Visual Loss; Prevalence of Structural Abnormalities of the Retinal Nerve Fiber Layer (RNFL) and Ganglion Cell Layer Complex (GCLC) by OCT in Veterans with Traumatic Brain Injury (TBI). Invest. Ophthalmol. Vis. Sci. 2013;54(15):2360.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To determine the prevalence of structural loss of neurons in the retina of veterans with a history of TBI compared to an age matched control group of veterans.

 
Methods
 

Cirrus volume OCT scans of the optic nerve and macula were obtained in 54 veterans with a history of TBI and 25 control veterans. The volume scans were segmented in 3 dimensions to derive the thickness of the RNFL and the GCLC using a graph-based software approach developed at the University of Iowa and was compared to the Cirrus proprietary software analysis.

 
Results
 

Using the 3D software segmentation of retinal layers, thinning of the average RNFL below the 5th percentile of control patients occurred in 14.8% (8/54) in right eyes and 7.6% (4/53) in left eyes. Thinning of the average GCLC occurred in 24.5% (13/53) in right eyes and 14.8% (8/54) in left eyes. The 3D segmentation of the RNFL and GCLC was significantly correlated with the Cirrus 2D segmentation and showed fewer outlier values due to artifacts.

 
Conclusions
 

OCT analysis showed almost twice the prevalence of abnormalities in the retinal ganglion cell layer complex compared to the RNFL in veterans with TBI. Ongoing investigations will determine correlation between structural loss and visual field loss and neurological deficits.

     
Keywords: 742 trauma • 613 neuro-ophthalmology: optic nerve • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)  
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