Purchase this article with an account.
Randy Kardon, Mona Garvin, Jui-Kai Wang, Kimberly Cockerham, Susan Anderson, Jan Full, Sonne Lemke, Glenn Cockerham, Iowa City VA RR&D Center of Excellence for the Prevention and Treatment of Visual Loss; Prevalence of Structural Abnormalities of the Retinal Nerve Fiber Layer (RNFL) and Ganglion Cell Layer Complex (GCLC) by OCT in Veterans with Traumatic Brain Injury (TBI). Invest. Ophthalmol. Vis. Sci. 2013;54(15):2360.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To determine the prevalence of structural loss of neurons in the retina of veterans with a history of TBI compared to an age matched control group of veterans.
Cirrus volume OCT scans of the optic nerve and macula were obtained in 54 veterans with a history of TBI and 25 control veterans. The volume scans were segmented in 3 dimensions to derive the thickness of the RNFL and the GCLC using a graph-based software approach developed at the University of Iowa and was compared to the Cirrus proprietary software analysis.
Using the 3D software segmentation of retinal layers, thinning of the average RNFL below the 5th percentile of control patients occurred in 14.8% (8/54) in right eyes and 7.6% (4/53) in left eyes. Thinning of the average GCLC occurred in 24.5% (13/53) in right eyes and 14.8% (8/54) in left eyes. The 3D segmentation of the RNFL and GCLC was significantly correlated with the Cirrus 2D segmentation and showed fewer outlier values due to artifacts.
OCT analysis showed almost twice the prevalence of abnormalities in the retinal ganglion cell layer complex compared to the RNFL in veterans with TBI. Ongoing investigations will determine correlation between structural loss and visual field loss and neurological deficits.
This PDF is available to Subscribers Only