June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Impaired Vascular Endothelial Function in Patients with Diabetic Macular Edema
Author Affiliations & Notes
  • Kengo Takahashi
    Ophthalmotology, Asahikawa Medical University, Asahikawa, Japan
  • Taiji Nagaoka
    Ophthalmotology, Asahikawa Medical University, Asahikawa, Japan
  • Akihiro Ishibazawa
    Ophthalmotology, Asahikawa Medical University, Asahikawa, Japan
  • Kenji Sogawa
    Ophthalmotology, Asahikawa Medical University, Asahikawa, Japan
  • Akitoshi Yoshida
    Ophthalmotology, Asahikawa Medical University, Asahikawa, Japan
  • Footnotes
    Commercial Relationships Kengo Takahashi, None; Taiji Nagaoka, None; Akihiro Ishibazawa, None; Kenji Sogawa, None; Akitoshi Yoshida, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2399. doi:
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      Kengo Takahashi, Taiji Nagaoka, Akihiro Ishibazawa, Kenji Sogawa, Akitoshi Yoshida; Impaired Vascular Endothelial Function in Patients with Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2399.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

The retinal vascular endothelial dysfunction may play a role in the breakdown of the blood-retinal barrier and leakage of plasma from retinal vessels and capillaries, resulting in diabetic macular edema (DME). To determine if the vascular endothelial function is involved in the pathogenesis of DME, we measured brachial artery flow-mediated vasodilation (FMD) in patients with diabetes.

 
Methods
 

Twenty-three patients with type 2 diabetes mellitus (DM) and nonproliferative diabetic retinopathy were enrolled. Based on optical coherence tomography and fluorescein angiography findings, the patients were divided into 2 groups: the DME(+) group (n=12; mean age, 65.9 ± 7.6 years) and the DME(-) group (n=11; mean age, 64.1 ± 10.3 years). We evaluated the logarithm of the minimum angle of resolution visual acuity (logMAR VA) and central macular thickness (CMT). Using high-resolution ultrasonographic imaging, we evaluated the FMD by measuring changes in the brachial artery diameter during reperfusion after arterial occlusion.

 
Results
 

The mean CMTs ± standard deviations (SDs) were 410.2 ± 131.1 μm and 229.9 ± 33.5 μm in DME(+) and DME(-) groups, respectively. The mean logMAR VAs ± SDs were 0.42 ± 0.38 and 0.10 ± 0.07 respectively. There were significant differences in the CMT and logMAR VA between the two groups (p<0.001 for both comparisons). The group-averaged FMD values were significantly lower in the DME(+) group (3.1 ± 1.5%) compared with the DME(-) group (5.4 ± 2.7%, p = 0.035). In the DME(+) group, the FMD value was not significantly correlated with the CMT and logMAR VA.

 
Conclusions
 

The current results showed that the FMD in patients with DME with type 2 DM was lower than in patients without DME, suggesting that impaired systemic vascular endothelial function might be associated with the pathogenesis of DME.

 
Keywords: 499 diabetic retinopathy • 505 edema  
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