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Shin Yoshitake, Tomoaki Murakami, Akihito Uji, Ken Ogino, Noriyuki Unoki, Takahiro Horii, Masayuki Hata, Shigeta Arichika, Kazuaki Nishijima, Nagahisa Yoshimura; Association between Near Infrared Autofluorescence and Optical Coherence Tomography in Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2403.
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© ARVO (1962-2015); The Authors (2016-present)
To study the association of near infrared autofluorescence (NIR-AF) imaging with spectral-domain optical coherence tomography(SD-OCT) findings and logarithm of minimal angle resolution visual acuity (logMAR VA) in diabetic macular edema (DME).
Consecutive 87 eyes of 63 patients who had center-involved DME and on whom NIR-AF and OCT images with sufficient quality were obtained were included in this retrospective study. NIR-AF images were acquired using Heidelberg Retina Angiography 2 (HRA2), and the retinal sectional images were evaluated by Spectralis OCT. The relationship between the characteristics of NIR-AF images, OCT findings, and logMAR VA were investigated.
Thirty-eight eyes with mosaic pattern NIR-AF at the macula had worse VA (0.372±0.251 vs. 0.248±0.221, p=0.019) and more damaged external limiting membrane (ELM) (47.4% vs. 14.3%, p=0.002) than those without this finding. Twenty-seven of 51 eyes with foveal cystoid spaces were accompanied with definite outlines of the cystoid spaces in NIR-AF images. The eyes with such outlines had worse VA (0.386±0.242 vs. 0.192±0.207, p=0.003), more damaged ELM (40.7% vs. 12.5%, p=0.031), and greater central thickness (486.7±122.0μm vs. 408.3±88.5μm, p=0.011) than those without the outlines.
NIR-AF showed mosaic pattern and outline of cystoid spaces in DME, in association with VA and OCT findings, which suggests the clinical relevance as well as the pathogenesis in DME.
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