June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Retinal morphometry changes observed in vivo measured with SD-OCT after pan-retinal photocoagulation in patients with proliferative diabetic retinopathy
Author Affiliations & Notes
  • Christoph Mitsch
    Ophthalmology and Optometrics, Medical University of Vienna, Vienna, Austria
  • Matthias Bolz
    Ophthalmology and Optometrics, Medical University of Vienna, Vienna, Austria
  • Berthold Pemp
    Ophthalmology and Optometrics, Medical University of Vienna, Vienna, Austria
  • Andreas Reitner
    Ophthalmology and Optometrics, Medical University of Vienna, Vienna, Austria
  • Christoph Scholda
    Ophthalmology and Optometrics, Medical University of Vienna, Vienna, Austria
  • Ursula Schmidt-Erfurth
    Ophthalmology and Optometrics, Medical University of Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships Christoph Mitsch, None; Matthias Bolz, None; Berthold Pemp, None; Andreas Reitner, None; Christoph Scholda, None; Ursula Schmidt-Erfurth, Alcon (C), Bayer Healthcare (C), Novartis (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2432. doi:
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      Christoph Mitsch, Matthias Bolz, Berthold Pemp, Andreas Reitner, Christoph Scholda, Ursula Schmidt-Erfurth, Diabetic Retinopathy Research Group (DRRG) Vienna; Retinal morphometry changes observed in vivo measured with SD-OCT after pan-retinal photocoagulation in patients with proliferative diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2432.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To analyze the morphometric changes of distinct retinal layers measured around the optic disc by SD-OCT after pan-retinal photocoagulation

Methods: Patients were examined monthly with Fluorescence Angiography (FA) following a specific examination protocol for diabetic retinopathy and a peri-papillary ring-scan with Spectral-Domain Optical Coherence Tomography before and after undergoing a single-session pan-retinal photocoagulation during 6 months. Thickness measurements of distinct retinal layers were then performed and analyzed.

Results: One month after pan-retinal photocoagulation a significant increase of average peripapillary outer nuclear layer (p = 0.007) and whole retinal thickness (p = 0.006) was found. This was followed by a slow decline to baseline values over the following five months. The mean combined thickness of the retinal pigment epithelium and the photoreceptor cell layer was significantly reduced one month after laser treatment (p < 0.001). This decrease was followed by a slow increase until month 6, but did not reach original thickness values.

Conclusions: Pan-retinal photocoagulation leads to diffuse, but reversible morphometric changes of retinal layers measurable by peripapillary OCT. The found short-term increase of retinal thickness can be mainly attributed to an increase of outer nuclear layer thickness and was accompanied by a permanent attenuation of retinal pigment epithelium and photoreceptor cell layer. The reversible changes of peripapillary retinal structure observed in-vivo could be interpreted as signs of diffuse retinal inflammation following laser treatment.

Keywords: 499 diabetic retinopathy • 578 laser • 557 inflammation  
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