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Gokcen Gokce, Gungor Sobaci, Ali Hakan Durukan, Fazil Cuneyt Erdurman; Correlations Between Functional and Structural Changes in Treatment of Macular Edema Secondary to Branch Retinal Vein Occlusion. Invest. Ophthalmol. Vis. Sci. 2013;54(15):252.
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© ARVO (1962-2015); The Authors (2016-present)
To elucidate values of optical coherence tomography (OCT) based macular thickness assessment methods in definition of correlations between best corrected visual acuity (BCVA) and macular thickness values in different treatment methods of macular edema secondary to branch retinal vein occlusion (BRVO).
Sixty-two patients treated with intravitreal triamcinolone (IVTA) (group 1, n=26), intravitreal bevacizumab (IVB) (group 2, n=36), for treatment-naive, chronic, center-involving, macular edema secondary to BRVO were included. In each group, correlation between changes in BCVA and central macular thickness (CMT) values recorded during 12 months (1-3-6-12) follow-up were defined, regarding four CMT assessment methods including absolute change in retinal thickness (ACRT), relative change in retinal thickness (RCRT), relative change in retinal thickening (RCRTing), and logaritmic changes in retinal thickness (LCRT).
In IVTA group, the most correlated OCT parameters with the logMAR improvements were RCRTing in 1st month visit (r=0.38, p=0,05), LCRT and RCRT in 3rd month visit (r=0.51, p<0,01), ACRT (r=0.51, r=0.52 respectively p<0,01) in other visits. In IVB group the most correlated OCT parameters with the logMAR improvements were RCRTing in 1st, 3rd and 12th month visits (r=0.41, r=0.53 p<0.05 respectively; r=0.30 p=0.07), LCRT and RCRT in 6th month visit (r=0.31, p=0,06).
RCRTing in eyes treated with IVB seem to be the method of choice to analyse correlation between BCVA and CMT values in macular edema secondary to BRVO.
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