June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
The spectrum of inflammatory ocular involvement in systemic lupus erythematosus in a multidisciplinary uveitis unit
Author Affiliations & Notes
  • Laura Pelegrin
    Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Spain
  • Alfredo Montehermoso
    Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Spain
  • Marc Figueras
    Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Spain
  • Maite Sainz de la Maza
    Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Spain
  • Bernardo Sanchez-Dalmau
    Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Spain
  • Victor Llorens
    Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Spain
  • Blanca Molins
    Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Spain
  • Marina Mesquida
    Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Spain
  • Gerard Espinosa
    Autoimmune Disease, Hospital Clinic de Barcelona, Barcelona, Spain
  • Alfredo Adan Civera
    Ophthalmology, Hospital Clinic de Barcelona, Barcelona, Spain
  • Footnotes
    Commercial Relationships Laura Pelegrin, None; Alfredo Montehermoso, None; Marc Figueras, None; Maite Sainz de la Maza, Allergan (C), Alcon, Labs (R), Merck Sharp and Dohme (R); Bernardo Sanchez-Dalmau, None; Victor Llorens, None; Blanca Molins, None; Marina Mesquida, None; Gerard Espinosa, None; Alfredo Adan Civera, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2522. doi:
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      Laura Pelegrin, Alfredo Montehermoso, Marc Figueras, Maite Sainz de la Maza, Bernardo Sanchez-Dalmau, Victor Llorens, Blanca Molins, Marina Mesquida, Gerard Espinosa, Alfredo Adan Civera; The spectrum of inflammatory ocular involvement in systemic lupus erythematosus in a multidisciplinary uveitis unit. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2522.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To describe the inflammatory ocular manifestations of patients with systemic lupus erythematosus (SLE) at a multidisciplinary uveitis unit

Methods: Retrospective chart review of patients with SLE in a tertiary referral center between 2007 and 2012 was performed. All patients have undergone complete rheumatologic and ophthalmic examination including visual acuity, slit-lamp examination of the anterior segment and fundus examination. Fluorescein angiography and optical coherence tomography were performed if they were required.

Results: Twenty-three patients presented inflammatory ocular manifestations related to SLE. Patients complained of ophthalmologic disturbances with blurry vision and ocular redness as the most common symptoms. A decrease in the visual acuity was detected in 16 patients (69.6%) mostly due to retinal involvement, optic neuritis and anterior uveitis. Anterior uveitis was found in 8 patients (34.8%), peripheral ulcerative keratitis in 1 patient and diffuse scleritis in 4 patients (17.4%). Changes in retina were found in 7 patients (30.4%); the most frequent was retinal vein occlusion (central retinal vein occlusion in 2 patients and branch retinal vein occlusion in 2 patients) followed by hypertensive retinopathy with serous retinal detachment in 1 patient, occlusive vasculopathy in 1 patient and central serous choroidopathy due to corticosteroids in 1 patient. Three patients (13%) showed neuro-ophthalmological symptoms, 1 patient showed rotatory nistagmus related to central nervous system involvement, 1 patient showed optic neuritis and the remaining presented bitemporal hemianopsy.

Conclusions: Ocular manifestations in SLE can affect any structure in the eye. The most visually devastating damage occurs secondary to optic nerve involvement and retinal vaso-occlusion. Anterior uveitis is not an uncommon manifestation of SLE; physicians must be aware of this involvement since it can be treated without serious visual loss.

Keywords: 432 autoimmune disease • 746 uveitis-clinical/animal model  
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