June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Corneal hysteresis and glaucoma-related quantitative traits in the EPIC-Norfolk Eye Study
Author Affiliations & Notes
  • Anthony Khawaja
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
  • Michelle Chan
    Division of Genetics and Epidemiology, UCL Institute of Ophthalmology, London, United Kingdom
  • David Broadway
    Department of Ophthalmology, Norfolk & Norwich University Hospital, Norwich, United Kingdom
  • David Garway-Heath
    NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • Robert Luben
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
  • Kay-Tee Khaw
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
  • Paul Foster
    Division of Genetics and Epidemiology, UCL Institute of Ophthalmology, London, United Kingdom
    NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom
  • Footnotes
    Commercial Relationships Anthony Khawaja, None; Michelle Chan, None; David Broadway, None; David Garway-Heath, Moorfields MDT (P), Carl Zeiss Meditec (F), Heidelberg Engineering (F), Reichert Technoloies (F), Ziemer Ophthalmic Systems AG (F), Pfizer Inc (F), Allergan (F), Allergan (C), Allergan (R), Alcon (C), Alcon (R), Bausch & Lomb (R), Merck (R), Santen (R), Quark (C), Teva (C), Topcon (F), OptoVue (F); Robert Luben, None; Kay-Tee Khaw, None; Paul Foster, Carl Zeiss Meditech (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2654. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Anthony Khawaja, Michelle Chan, David Broadway, David Garway-Heath, Robert Luben, Kay-Tee Khaw, Paul Foster, ; Corneal hysteresis and glaucoma-related quantitative traits in the EPIC-Norfolk Eye Study. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2654.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose
 

Controversy exists regarding whether corneal biomechanical properties are related to glaucoma risk independently of intraocular pressure. The aim of this study was to determine if an association exists between corneal hysteresis (CH) and glaucoma-related quantitative traits in a population-based sample.

 
Methods
 

Ophthalmic examination took place cross-sectionally between 2004-2011. Goldmann-correlated intraocular pressure (IOP) and CH were measured using the Ocular Response Analyzer (single best value from 3 readings). Average retinal nerve fibre layer (RNFL) thickness and the nerve fibre indicator (NFI) were measured using the GDxVCC (quality score ≥7). Optic disc rim area and linear cup-to-disc ratio (CDR) were measured using the HRT II (topographic SD ≤40). Axial length was measured using the IOLMaster. Linear regression models were used to examine the association between CH and RNFL/disc parameters. Models with GDx parameters were adjusted for typical scan score (TSS) to handle scans with atypical retardation, and models with HRT parameters were adjusted for disc area. Maximally adjusted models were further adjusted (linearly) for IOP, axial length, age, sex, body mass index, height and systolic blood pressure. Generalised estimating equations were used to analyse data from both eyes of participants.

 
Results
 

Complete data were available from 8,615 eyes of 5,354 predominantly white participants. The mean age was 67yrs (48-89) and 43% were men. Summary measures for the 8,615 eyes are shown in Table 1. Table 2 summarises results from the regression analyses. Higher CH was significantly associated with a larger rim area (p<0.001), smaller linear CDR (p<0.001) and thicker RNFL (p<0.001) in maximally adjusted models. Higher CH was associated with lower NFI in crude analysis (p<0.001) but not following maximal adjustment (p=0.18). Results were similar if adjustment was for corneal-compensated IOP, rather than Goldmann-correlated values.

 
Conclusions
 

In a population of British adults, higher CH was significantly associated with RNFL and optic disc parameters in a direction suggestive of a protective effect against glaucoma. This may support the theory that corneal biomechanical measures reflect lamina properties and thus glaucoma risk. Residual confounding by IOP is another possible explanation for the association. Regression coefficients were small, indicating a small effect.

     
Keywords: 464 clinical (human) or epidemiologic studies: risk factor assessment • 627 optic disc • 610 nerve fiber layer  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×