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Saleema Kherani, Millena Bittencourt, Daniel Ferraz, Hongting Liu, Mehreen Ansari, Mohammad sadiq, Raafay Sophie, Rachel Annam, Yasir Sepah, Quan Dong Nguyen; Variation of Choroidal Thickness and Choroidal Vessel Diameter in Patients with White Dot Syndromes. Invest. Ophthalmol. Vis. Sci. 2013;54(15):27.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the variation of choroidal thickness and choroidal vessel diameter in eyes with white dot syndromes (WDS).
In this cross-sectional study, spectral domain-optical coherence tomography (SD-OCT) scans were acquired from 17 normal subjects (31 eyes) and 14 patients (17 eyes) with white-dot-syndromes, using Spectralis HRA+OCT™. In normal subjects, choroidal thickness (CTh) and choroidal vessel diameter (VD) were measured at 3 different OCT sections of a particular visit. Measurements were taken within 1 mm randomly selected along the fovea OCT horizontal line and 2mm superior and inferior to it. In subjects with WDS, chorioretinal lesions were identified and measurements of CTh and VD were obtained within 1 mm of each. A ratio (R) between the VD measurements and the corresponding CTh measurements was calculated and used for comparison between normal and patients with WDS.
Sixteen (51.6%) of the normal subjects and six (35.2%) of the WDS patients (punctate inner choroidopathy, multifocal choroiditis, birdshot chorioretinopathy, amongst others) were male. Mean age was 30.2 years for normal subjects and 45.2 years for patients. A statistically significant difference was noted between the mean CTh measurements of normal subjects and patients (p<0.001). Similarly, a statistically significant difference was noted between the mean VD measurements of the two groups (p<0.001). Mean “R” was noted to be 0.59 for normal subjects and 0.67 for the patients (<0.001), and their difference was statistically significant. Gender, age and location of measurement had no significant effect on the ratio between CTh and VD. Additional results are illustrated in table.
CTh and VD measurements may provide useful information in understanding the disease process in WDS. These values may also allow identification of patients with more severe and/or sub-clinical disease. Further analyses with a greater sample are recommended to evaluate the use of CTh and VD measurements as a predictor of inflammation in patients with WDS.
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