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Hao Wang, Le Feng, Fang Wang; Differentiating vitreous proteomes in proliferative diabetic retinopathy using high-performance liquid chromatography coupled to tandem mass spectrometry. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2703.
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The aim of this study was to compare the protein profile of vitreous humour from diabetic patients with proliferative diabetic retinopathy with that from nondiabetic subjects with idiopathic epiretinal macular membranes.
Vitreous humour from type 2 diabetic patients with PDR (n=8) and from nondiabetic subjects with idiopathic epiretinal macular membranes (n=8) were studied. The comparative proteomic analysis was performed using reversed phase high-performance liquid chromatography coupled to electrospray Ionization tandem mass spectrometry.
91 significant differentially expressed proteins (abundance ratio > 1.5, p < 0.05) were identified, including 37 and 54 proteins up- and downregulated in PDR vitreous compared with the control, respectively.
These data provide insight into the molecular events possibly involved in the pathogenesis of PDR and widen the scope of potential avenues for new therapies for PDR.
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