June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
Quantification and evaluation of bivariate contour ellipse area (BCEA) in different diseases after rehabilitation
Author Affiliations & Notes
  • Francesca Verboschi
    University of Rome "La Sapienza", Latina (LT), Italy
  • Vittoria De Rosa
    University of Rome "La Sapienza", Latina (LT), Italy
  • Chiara Di Crescenzo
    University of Rome "La Sapienza", Latina (LT), Italy
  • Gianmarco Rea
    University of Rome "La Sapienza", Latina (LT), Italy
  • Marco Mafrici
    University of Rome "La Sapienza", Latina (LT), Italy
  • Daniela Domanico
    University of Rome "La Sapienza", Latina (LT), Italy
  • Enzo Vingolo
    University of Rome "La Sapienza", Latina (LT), Italy
  • Footnotes
    Commercial Relationships Francesca Verboschi, None; Vittoria De Rosa, None; Chiara Di Crescenzo, None; Gianmarco Rea, None; Marco Mafrici, None; Daniela Domanico, None; Enzo Vingolo, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 2772. doi:
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      Francesca Verboschi, Vittoria De Rosa, Chiara Di Crescenzo, Gianmarco Rea, Marco Mafrici, Daniela Domanico, Enzo Vingolo; Quantification and evaluation of bivariate contour ellipse area (BCEA) in different diseases after rehabilitation. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2772.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To quantify BCEA in different diseases and to evaluate its change after rehabilitation with microperimetric biofeedback.

Methods: 64 patients (38 female and 26 male, mean age 75.87 years) were enrolled and 96 eyes were divided into different groups: 16 eyes with dry age-related macular degeneration (group 1), 12 eyes with advanced glaucoma (group 2), 11 eyes with central retinal vein occlusion (group 3), 11 eyes after surgery for macula-off retinal detachment (group 4), 11 eyes with amblyopia (group 5), 13 eyes with myopic maculopathy (group 6), 12 eyes with diabetic maculopathy (group 7), 10 eyes with retinitis pigmentosa (group 8). All the patients underwent the same rehabilitative protocol: microperimetry MP-1 (Nidek technologies, Padova, Italia), threshold strategy 4-2, Goldmann III stimolus, with fixation study that was quantified by calculating the BCEA; 10 training sessions, once a week, 10 minutes for each eye, with microperimetric biofeedback, repeated after 3 months. Statistical analysis was performed using t-test paired, p values less than 0.05 were considered statistically significant. For statistical analysis, BCEA values (deg ) were converted into their logarithms.

Results: After the training mean BCEA became from 7.51±2.48 deg to 3.85±2.93 deg in group 1 (p=0.02); mean BCEA became from 4.02±2.83 deg to 0.84±0.48 deg in group 2 (p=0.14); mean BCEA became from 3.72±4.85 deg to 2.18±2.22 deg in group 3 (p=0.42); mean BCEA became from 3.31±2.53 deg to 2.15±1.59 deg in group 4 (p=0.03); mean BCEA became from 3.18±2.55 deg to 2.15±1.32 deg in group 5 (p=0.06); mean BCEA became from 2.22±2.65 deg to 0.45±0.13 deg in group 6 (p=0.05); mean BCEA became from 3.38±3.42 deg to 1.72±1.72 deg in group 7 (p=0.02); mean BCEA became from 1.89±1.40 deg to 0.77±0.26 deg in group 8 (p=0.14).

Conclusions: The largest BCEA reduction after the training indicates a greater efficacy of microperimetric biofeedback especially in dry age-related macular degeneration, after surgery for macula-off retinal detachment, myopic maculopathy and diabetic maculopathy compared to glaucoma, central retinal vein occlusion, amblyopia and retinitis pigmentosa. The study of BCEA is useful and more sensitive instrument than Fujii classification to evaluate the stability of fixation especially in diseases with macular involvement.

Keywords: 584 low vision • 650 plasticity  

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