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Miguel Pedroza-Seres, Edson Robles, Diana González; Ocular manifestations of Granulomatosis with Polyangiitis from the “Institute of Ophthalmology Conde de Valenciana”. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2912.
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To describe the main clinical ocular manifestations and the immunosuppressive medication used in Granulomatosis with Polyangiitis in a tertiary eye care center (Insitute of Ophthalmology Conde de Valenciana).
Medical records of Granulomatosis with Polyangiitis patients were compiled and reviewed from September 2007 until August 2012. A database was made combining all the ocular clinical manifestations listed. Percentage of occurrence for each ocular disease as a first manifestation in Granulomatosis with Polyangeiitis were obtained and categorized. The immunosuppressive treatment was reviewed too.
Among the 34 patients identified, 53% have uniocular disease and 47 % have binocular disease. Anterior diffuse scleritis was the most frequent ocular manifestation affecting 32% of the population. Necrotizing scleritis was presented in 29% of the patients. PUK was the first manifestation in 15% of our population. Orbital disease appeared in 9%. Nodular scleritis were identified in 6%. Retinal vasculitis was infrequent affecting only 3% also anterior uveitis (3%). The main medication administered were oral cyclophosphamide and oral methotrexate in 41% of the patients each one, intravenous cyclophosphamide and azathioprine were used in 26.5%. Mycophenolate mofetilo was used in 6%. Only one patient was taking Anti TNF drugs.
The main ocular manifestation of Granulomatosis with Polyangiitis in our hospital was scleritis and the most common treatment used was oral cyclophosphamide and oral mthotrexate.
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