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Rajiv Shah, Sunir Garg; THe Efficacy and Outcomes of combination Intravitreal Foscarnet and Ganciclovir in Herpetic Retinitis. Invest. Ophthalmol. Vis. Sci. 2013;54(15):2920.
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To evaluate the long-term outcomes and safety for combination intravitreal foscarnet and ganciclovir in the treatment of herpetic retinitis.
All cases of herpetic retinitis (Acute Retinal Necrosis, Progressive Outer Retinal Necrosis, and CMV retinitis) were identified from 2008-2012 that were treated with combination intravitreal foscarnet and ganciclovir in addition to standard systemic antiviral therapy. Outcomes of time to retinal detachment, visual acuity, and safety of dual simulataneous intravitreal antivral therapy were evaluated.
7 eyes were identified with herpetic retinitis that were treated with dual injection therapy. There were no cases of increased injection related endopthalmitis nor complications related to the increased injeciton. Dual injection therapy was found safe and no retinal detachments were seen several months after dual injection therapy in all herpetic retinitis eyes.
Injection of Intravitreal foscarnet and ganciclovir is safe and efficacious in the treatment of herpetic retinitis. Dual injection therapy may lead to a lower rate of retinal detachment in herpetic retinitis eyes.
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