June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Test-Retest Reliability of Microperimetry Using the Optos OCT SLO in Eyes With and Without Known Retinal Diseases
Author Affiliations & Notes
  • Hyun Soo Jang
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Yasir Sepah
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Millena Bittencourt
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Mohammad Sadiq
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Owhofasa Agbedia
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Hongting Liu
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Mehreen Ansari
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Zubir Rentiya
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Daniel Ferraz
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Quan Dong Nguyen
    Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD
  • Footnotes
    Commercial Relationships Hyun Soo Jang, None; Yasir Sepah, None; Millena Bittencourt, None; Mohammad Sadiq, None; Owhofasa Agbedia, None; Hongting Liu, None; Mehreen Ansari, None; Zubir Rentiya, None; Daniel Ferraz, None; Quan Dong Nguyen, Genentech (F), Regeneron (F), Lux Biosciences (F), Abbott (F), GSK (F), Santen (F), Santen (C), Bausch and Lomb (C), Optos (F), Heidelberg Engineering (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 3432. doi:
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      Hyun Soo Jang, Yasir Sepah, Millena Bittencourt, Mohammad Sadiq, Owhofasa Agbedia, Hongting Liu, Mehreen Ansari, Zubir Rentiya, Daniel Ferraz, Quan Dong Nguyen; Test-Retest Reliability of Microperimetry Using the Optos OCT SLO in Eyes With and Without Known Retinal Diseases. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3432.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate the test-retest reliability of Optos (Optos, Inc, Scotland, UK) OCT SLO microperimetry (MP) device in eyes with and without known retinal diseases.

 
Methods
 

Thirty six eyes of 19 subjects (ages 20-53, mean 29) with no known retinal diseases and 10 eyes of 5 subjects (ages 29-76, mean 52) with known retinal diseases were scanned. All tests were performed using the Optos OCT SLO. For each eye, a fixation test and spectral domain optical coherence tomography were obtained before the MP. Three consecutive fundus-aligned MP sessions for each eye with a maximum of 2-minute interval between the sessions were performed using the following settings: a customized 9-point pattern, 200 ms stimulus duration, Goldmann III size, 4-2-1 dB staircase strategy, 10 dB initial brightness, and red cross as the fixation target. The 9 points consisted of a 3x3 upright square lattice centered at the fovea, having a 1.5° angle between the center and every corner point (Figure). The point sensitivities were recorded.

 
Results
 

Sensitivities and variances are recorded in the Table. Friedman Test showed no significant differences in the mean sensitivities across the 3 sessions in both groups (p>0.7 for both). The overall inter-session variances in normal (1.03 ± 0.07) and diseased (2.43 ± 0.51) groups were significantly different (p=0.05, Mann-Whitney Test). The variances of 9 points were significantly different in both groups (p<0.05, Friedman Test). The points with greatest variances are highlighted in the Table.

 
Conclusions
 

The Optos OCT SLO microperimeter produces reliable test results with no significant differences in mean sensitivities among sessions. Eyes with retinopathies were found to have greater inter-session variance than those without. Therefore, interpretation of the changes in retinal sensitivities among eyes with pathologies must take into consideration the differences in test variances between normal and diseased eyes. Additional studies on the MP variances in different and larger diseased groups are indicated.

     
Keywords: 642 perimetry • 758 visual fields • 688 retina  
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