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Maher Saleh, meillat mathieu, Mélanie Bidaut-Garnier, Perle TUMAHAI, Guillaume Debellemaniere, Mathieu Flores, Michel Montard, Bernard Delbosc; Evaluation of cone density after retinal detachment surgery using an Adaptive Optics camera. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3453.
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© ARVO (1962-2015); The Authors (2016-present)
To assess macular cone photoreceptors density in human eyes operated for retinal detachment (RD) and in contralateral healthy eyes.
Patients operated for RD with macular involvement were imaged using the RTX-1 Adaptive Optics (AO) device from Imagine eyes™ (Orsay, France), 6 weeks after the surgery. Cone density (cells/mm2) at a fixed distance from the fovea (1 °), spacing between cells (µ) and percentage of hexagonal cells calculated on Voronoï diagrams, were obtained using AO Detect v.0.1, the proprietary software of the device. Group 1 represented the eyes with history of RD and group 2 the contralateral eyes. Visual acuity (logMAR), refraction, axial length (mm) and the thickness of the different choroid and retinal layers (RPE, IS/OS, LME lines) imaged by SD-OCT (Spectralis®, Heidelberg), were also compared to the cone densities.
Thirty eyes from 15 patients were studied. Visual acuities decreased in group 1 (0.34 vs 0.1 in group 2, paired t test, p<0.05). There was a reduction in cone density in group 1 (14368±4761/mm2) compared to group 2 (19240±3894/mm2) (p=0.002). In group 1, spacing between cones was increased (11.16±3.34 µ vs 8.65±1.95µ, p=0.01), while the proportion of hexagonal cells was reduced (36.11±5.29% vs. 42.08± 5.16 %, p=0.01). There was also a negative correlation between overall cone densities and visual acuities (R2=0.45). Cone density was also correlated to the thickness of the RPE hyperreflective layer on OCT (R2= 0.21, p=0.02) but neither with central macular thickness nor choroidal thickness.
Adaptive Optics allowed in vivo imaging of the macular phoreceptors in eyes operated for RD. The cone density was correlated to the visual acuity. OA could represent a valuable prognostic tool after RD surgery.
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