June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Recovery of photoreceptors in the macula of idiopathic choroidal neovascularization observed with adaptive optics fundus camera
Tomoko Nakamura; Toshihiko Oiwake; Tomoko Ueda; Akio Miyakoshi; Atsushi Hayashi
Author Affiliations & Notes
  • Tomoko Nakamura
    University of Toyama, Toyama, Japan
  • Toshihiko Oiwake
    University of Toyama, Toyama, Japan
  • Tomoko Ueda
    University of Toyama, Toyama, Japan
  • Akio Miyakoshi
    University of Toyama, Toyama, Japan
  • Atsushi Hayashi
    University of Toyama, Toyama, Japan
  • Footnotes
    Commercial Relationships Tomoko Nakamura, None; Toshihiko Oiwake, None; Tomoko Ueda, None; Akio Miyakoshi, None; Atsushi Hayashi, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 3454. doi:
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      Tomoko Nakamura, Toshihiko Oiwake, Tomoko Ueda, Akio Miyakoshi, Atsushi Hayashi; Recovery of photoreceptors in the macula of idiopathic choroidal neovascularization observed with adaptive optics fundus camera. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3454.

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Abstract

Purpose: To observe recovery of photoreceptors in the macula of idiopathic choroidal neovascularization (ICNV) patients and to assess correlations between cone analyses and OCT images.

Methods: Three eyes of 3 patients with ICNV were studied. All patient received intravitreal injections of 1.25mg bevacizumab (IVB). After subretinal fluid was resolved, adaptive optics (AO) images were obtained with rtx1TM (Imagine Eyes ,France) and cone analyses were performed. Changes in OCT and visual acuity were examined during the follow up.

Results: After subretinal fluid was resolved by IVB, decimal visual acuity of all patients improved to 1.0. In AO images, cone photoreceptors were not observed in the area with absent or disrupted photoreceptor inner segment / outer segment (IS/OS) junction and cone outer segment tips (COST) line in OCT images. In the area with intact IS/OS junction and absent or disrupted COST line, cone photoreceptors returned to be observed after IVB. Cone density, cone spacing, and voronoi domains were improved with the recovery of the COST line in OCT.

Conclusions: Recovery of cone photoreceptors in the macula of ICNV patients after IVB was associated with changes in OCT images.

Keywords: 453 choroid: neovascularization • 550 imaging/image analysis: clinical • 648 photoreceptors  
© 2013, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2015 Association for Research in Vision and Ophthalmology.
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