June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Measures of Intraocular Pressure Variation and Risk of Developing Open-angle Glaucoma: The Los Angeles Latino Eye Study
Author Affiliations & Notes
  • Xuejuan Jiang
    Doheny Eye Institute, University of Southern California, Los Angeles, CA
    Preventive Medicine, University of Southern California, Los Angeles, CA
  • Rohit Varma
    Doheny Eye Institute, University of Southern California, Los Angeles, CA
    Preventive Medicine, University of Southern California, Los Angeles, CA
  • Mina Torres
    Doheny Eye Institute, University of Southern California, Los Angeles, CA
  • Stanley Azen
    Preventive Medicine, University of Southern California, Los Angeles, CA
  • Brian Francis
    Doheny Eye Institute, University of Southern California, Los Angeles, CA
  • Vikas Chopra
    Doheny Eye Institute, University of Southern California, Los Angeles, CA
  • Betsy Bao-Thu Nguyen
    Doheny Eye Institute, University of Southern California, Los Angeles, CA
  • Footnotes
    Commercial Relationships Xuejuan Jiang, None; Rohit Varma, Allergan (C), AqueSys (C), Genentech (C), Merck & Co. Inc (C), Replenish (C), Genentech (F), National Eye Institute (F); Mina Torres, None; Stanley Azen, None; Brian Francis, Allergan (F), Merck (F), Neomedix (C), Endooptiks (C), Lumenis (F); Vikas Chopra, Allergan, Inc. (C); Betsy Bao-Thu Nguyen, allergan (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 3485. doi:
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    • Get Citation

      Xuejuan Jiang, Rohit Varma, Mina Torres, Stanley Azen, Brian Francis, Vikas Chopra, Betsy Bao-Thu Nguyen, ; Measures of Intraocular Pressure Variation and Risk of Developing Open-angle Glaucoma: The Los Angeles Latino Eye Study. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3485.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To determine whether measures of intraocular pressure (IOP) variation are associated with the development of open-angle glaucoma (OAG) in an adult Latino population.

Methods: The Los Angeles Latino Eye Study is a population-based, prospective cohort study of self-identified, 40+ years old Mexican Americans residing in Los Angeles, California. For the current analysis, a total of 3,666 study participants who were free of OAG at the study baseline and had completed four-year follow-up clinical examinations were included. Similarly designed interviews and comprehensive ophthalmologic examinations were conducted at both the baseline and the follow-up. OAG was defined as the presence of an open angle and a glaucomatous visual field abnormality and/or evidence of glaucomatous optic nerve damage in at least one eye. Four different measures (mean, peak, standard deviation, and range) of inter-visit IOP were derived from six IOP readings obtained at the baseline visit and the four-year follow-up visit. Multivariate logistic regression was performed to assess the association between the four measures of inter-visit IOP and the risk of developing OAG in four years.

Results: Among the four measures of inter-visit IOP, peak inter-visit IOP was the best independent predictor of the incidence of OAG. Further examination revealed that the association between inter-visit IOP measures and incidence of OAG varied for individuals with different levels of IOP. Among participants with low mean IOP (≤18 mmHg), higher levels of peak, standard deviation, and range of inter-visit IOP were all significantly associated with a higher risk of developing OAG (P<0.05), while mean IOP were not associated with risk of developing OAG. Among participants with high mean IOP (>18 mmHg), higher levels of mean and peak of inter-visit IOP were significantly associated with higher risk of developing OAG, while standard deviation and range of inter-visit IOP were not associated with risk of developing OAG with or without adjustment for mean IOP. Results were similar when participants were grouped according to mean IOP <15 and ≥15 mmHg.

Conclusions: Overall, peak inter-visit IOP was the best predictor of the incidence of OAG. Greater variation in IOP was associated with a higher risk of developing OAG among individuals with low mean IOP, but not among individuals with high mean IOP.

Keywords: 568 intraocular pressure • 464 clinical (human) or epidemiologic studies: risk factor assessment  
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