Purchase this article with an account.
Elia Chavez, Jose Paczka, Abraham Soto-Gomez, Miriam Ramos-Hernandez; First-degree Consanguinity as a risk factor to developing primary open-angle Glaucoma in Mexican families. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3518.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To investigate the risk to developing primary open-angle glaucoma (POAG) among Mexican individuals with first-degree relatives affected by POAG.
Fifty-three persons (29 females, 24 males; mean age of 47.96 ± 23.04 years) belonging to eight families in which several members are positive for POAG were prospectively assessed. All 53 individuals were comprehensively examined by the same ophthalmologist. Glaucoma suspects derived from such assessment underwent a battery of specialized tests (automated achromatic static perimetry and optical coherence tomography). In addition, 44 visually healthy controls (25 females, 19 males; mean age of 49.11 ± 0.11 years) were also ophthalmologically evaluated. Relative risk to develop POAG was estimated from a weighted family score based on the number of affected first-degree relatives.
Twenty-eight POAG patients (18 females, 10 males; mean age of 56.28 ± 16.72 years)were younger, more commonly represented by males, and with wider vertical c/d ratios as compared to individuals without glaucoma as well as to the controls. Relative risk ratio to develop POAG among members of the studied family members is 1.86 (95% CI, 1.18-2.90; P = 0.006).
Our study confirmed that first-degree consanguinity in a sample of Mexican individuals is associated with a risk of having POAG approximately twice as much for members with a higher family score.
This PDF is available to Subscribers Only