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Jennyfer Zerbib, Giuseppe Querques, Nathalie Massamba, Nathalie Puche, Julien Tilleul, Franck Lalloum, Mayer Srour, Eric Souied; RETICULAR PATTERN DYSTROPHY: A SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY ANALYSIS. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3635.
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To analyze the outer retinal and retinal pigment epithelium (RPE) features of reticular pattern dystrophy using spectral-domain optical coherence tomography (SD-OCT).
Consecutive patients with reticular pattern dystrophy underwent a complete ophthalmologic examination, including assessment of best-corrected visual acuity (BCVA), fundus biomicroscopy, and SD-OCT (Spectralis SD-OCT, Heidelberg Engineering). Specific SD-OCT outer retinal and RPE features were analyzed by 3 authors.
Twenty-two eyes of 13 patients (6 males, 7 women, mean age 68.6 years±14.5) were included for analysis. In the foveal area, the RPE layer appeared normal in 45.5% of scans, while small RPE elevations and RPE bumps were detected in 31.8% and 22.7% of scans, respectively. The SD-OCT scans showed disruption of inner segment/outer segment (IS/OS) junction in 54.6% of scans, a slight IS/OS elevation in 59.1% of scans and absence in 45.5% of scans. The outer limiting membrane (OLM), appeared disrupted in 50.0% of scans, absent in 22.7% of scans, and elevated in 63.6% of scans. Hypereflective subretinal material accumulation or hyporeflective subretinal lesions in the retrofoveolar region, were detected in 70% and in 20% of scans, respectively. SD-OCT showed hyporeflective retinal pseudocysts in 13.6% of scans.
In this study on reticular pattern dystrophy, SD-OCT showed disruption of RPE layer and RPE bumps. Outer retinal changes included disruption and absence of both IS/OS junction and OLM. Hypereflective subretinal material accumulation or hyporeflective subretinal lesions, and hyporeflective retinal pseudocysts were also noted.
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