June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Association between vitamin D status and age-related macular degeneration (AMD) by complement factor H (CFH) Y402H genotype
Author Affiliations & Notes
  • Amy Millen
    Social and Preventive Medicine, University at Buffalo, The State University of New York, Buffalo, NY
  • Kristin Meyers
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI
  • Zhe Liu
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI
  • Corinne Engelman
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI
  • Erin LeBlanc
    Center for Health Research, Kaiser Permanente NW, Portland, OR
  • Robert Wallace
    Department of Epidemiology, University of Iowa, Iowa City, IA
  • Lesley Tinker
    Fred Hutchinson Cancer Research Center, Seattle, WA
  • Sudha Iyengar
    Department of Epidemiology & Biostatistics, Case Western Reserve University, Cleveland, OH
  • Julie Mares
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI
  • Footnotes
    Commercial Relationships Amy Millen, Mushroom Council (F); Kristin Meyers, None; Zhe Liu, None; Corinne Engelman, None; Erin LeBlanc, None; Robert Wallace, None; Lesley Tinker, None; Sudha Iyengar, None; Julie Mares, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 370. doi:
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    • Get Citation

      Amy Millen, Kristin Meyers, Zhe Liu, Corinne Engelman, Erin LeBlanc, Robert Wallace, Lesley Tinker, Sudha Iyengar, Julie Mares, ; Association between vitamin D status and age-related macular degeneration (AMD) by complement factor H (CFH) Y402H genotype. Invest. Ophthalmol. Vis. Sci. 2013;54(15):370.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

It is well established that the Y402H CFH polymorphism increases risk for AMD. Previous research shows that high versus low vitamin D status, assessed with serum concentrations of 25-hydroxyvitamin D [25(OH)D], is associated with decreased odds of AMD. Whether the vitamin D association is modified by genetic risk for AMD remains to be examined.

 
Methods
 

Using data from the Carotenoids in Age-Related Eye Disease Study, an ancillary study of the Women’s Health Initiative, we examined whether the association between serum [25(OH)D] and AMD was modified by presence of the CFH Y402H polymorphism. There were 1,230 postmenopausal women aged 50-79 at study baseline (1994-98) with complete genotype data and available serum samples. [25(OH)D] were assessed at baseline by competitive chemiluminescence immunoassay. Prevalent AMD (n=249) was assessed six years later by stereoscopic fundus photographs. Logistic regression was used to estimated odds ratios (ORs) and 95% confidence intervals (CIs) for early or late AMD by [25(OH)D] (<30, 30 to <50, ≥50 to <75, and ≥75 nmol/L) and CFH Y402H genotype (noncarrier, one risk allele, two risk alleles). The referent group was Y402H noncarriers with inadequate vitamin D status (<30 nmol/L).

 
Results
 

Among women with inadequate ([25(OH)D]<30 nmol/L) or adequate ([25(OH)D]>75 nmol/L) vitamin D status, having two risk alleles was associated with an increased odds of AMD but the odds was attenuated in those adequate vitamin D status (OR=4.30, 95% CI=1.21-15.20 and OR=1.56, 95% CI=0.54, 4.52, respectively). Among noncarriers and women with one risk allele, the odds of AMD was decreased in women with [25(OH)D]>75 (OR=0.82, 95% CI=0.29-2.33 and OR=0.89, 95% CI=0.34-2.35, respectively). In women with 2 risk alleles, having [25(OH)D]>75 lowered the odds for AMD 64% (OR=1.56, 95% CI=0.54, 4.52) relative to those with [25(OH)D]<30 (OR=4.30, 95% CI=1.21-15.20). The P for interaction between vitamin D status and genotype was 0.35. Further adjustment for use of hormone therapy, sunlight exposure and eye color did not alter the associations.

 
Conclusions
 

In this sample of postmenopausal women, the odds of AMD decreased with increasing [25(OH)D] across all genotypes, but most markedly among those with two risk alleles for the CFH Y402H genotype.

  
Keywords: 412 age-related macular degeneration • 539 genetics • 464 clinical (human) or epidemiologic studies: risk factor assessment  
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