June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Difference in ocular damage by 40 and 95 GHz exposure to rabbit eye
Author Affiliations & Notes
  • Masami Kojima
    Vis Res for Environmtl Hlth/Med Res Inst, Kanazawa Med Univ, Kahoku, Japan
    Medical Chemistry, Nursing school of Kanazawa Medical University, Kahoku, Japan
  • Nailia Hasanova
    Vis Res for Environmtl Hlth/Med Res Inst, Kanazawa Med Univ, Kahoku, Japan
  • Hiroshi Sasaki
    Vis Res for Environmtl Hlth/Med Res Inst, Kanazawa Med Univ, Kahoku, Japan
  • Kazuyuki Sasaki
    Vis Res for Environmtl Hlth/Med Res Inst, Kanazawa Med Univ, Kahoku, Japan
  • Footnotes
    Commercial Relationships Masami Kojima, None; Nailia Hasanova, None; Hiroshi Sasaki, None; Kazuyuki Sasaki, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 3869. doi:
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    • Get Citation

      Masami Kojima, Nailia Hasanova, Hiroshi Sasaki, Kazuyuki Sasaki, ; Difference in ocular damage by 40 and 95 GHz exposure to rabbit eye. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3869.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

Millimeter waves (MMW) are prevalent in high-speed wireless communication, automobile collision prevention systems and high-resolution radar imaging. We examined frequency (40 and 95 GHz) dependent differences of corneal damage in rabbit eye.

 
Methods
 

Pigmented rabbits (N=48, Dutch, 13-16 week-old) were exposed unilaterally to 95 GHz MMW at 200 mW/cm2 for 6 or 10 minutes, and 40 GHz MMW at 200, 300, 400 mW/cm2 for 6 min by lens antenna. Systemic anesthesia during exposure and ocular examination was induced by medetomidine hydrochloride (0.5 mg/kg). Ocular changes were evaluated by slit-lamp. Corneal surface temperature during exposure was recorded by thermograph camera (R300, NEC Avio). Microencapsulated thermochromic liquid crystal (MTLC) injected into the anterior chamber prior to exposure with color change recorded by video camera during exposure revealed heat transport.

 
Results
 

Corneal surface temperature following 95 GHz 200 mW/cm2 , 6 and 10 min exposure was 42.6±2.1 degrees Celsius (C) and 43.2±1.3 degrees C, respectively (NS). Representative ocular damage were diffuse corneal epithelial cell damage immediately after exposure, corneal epithelial defect and corneal edema 1 day after exposure. Exposure for 10 min caused more severe corneal epithelium defect (12/12 eyes) than for 6 min (4/7 eyes). Maximum corneal surface temperatures by 40 GHz at 200, 300 and 400 mW/cm2 were 41.4±1.1, 42.5±1.1, and 45.5±2.1 degrees C, respectively. Exposure for 6 min to 40 GHz at 200 mW/cm2 caused transient corneal diffuse damage (3/6 eyes) and at 300 mW/cm2 diffuse corneal epithelial damage (6/6 eyes). Diffuse corneal epithelial cell damage occurred immediately following exposure at 400 mW/cm2 (3/5 eyes), and corneal epithelial defect (2/4 eyes) and corneal edema (2/4) 1 day after. Morphological evaluation showed 95 GHz at 200 mW/cm2 and 40 GHz at 400 mW/cm2, for 6 min, caused similar damage. Corneal surface penetration depth of 40 and 95 GHz was 0.59 and 0.31 mm, respectively. MTLC analysis revealed that 40 GHz exposure transported heat to iris and lens by aqueous humor convection within 20 sec, compared to 60 sec by 95 GHz (Fig).

 
Conclusions
 

Ocular heat effects by 40 and 95 GHz MMW differed with 95 GHz being more severe. MMW penetration depth, heat transport, and dissipation from cornea play important roles in ocular damage.

 
 
Aqueous humor convection by 40 or 95 GHz exposure
 
Aqueous humor convection by 40 or 95 GHz exposure
 
Keywords: 670 radiation damage: light/UV • 482 cornea: epithelium • 421 anterior segment  
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