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Paul Beer, Paul Kaufman, Mary Ann Croft, Gregg Heatley, Jared McDonald, Alex Katz; Accommodative-Disaccommodative IOL with Zonular Capture Haptics. Invest. Ophthalmol. Vis. Sci. 2013;54(15):387.
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To determine if a single optic accommodative-disaccommodative IOL with Zonular Capture Haptics will exhibit desirable axial shift and accommodation.
Single optic, accommodative IOL’s with Zonular Capture Haptics were manufactured using a 5mm silicone optic from a commercially available IOL and haptics made from Prolene® suture material. Two such IOL’s were implanted into two Rhesus monkeys. The capsular bag was sectioned three weeks post implantation. Two weeks later UBM and plano perfusion lens imaging was performed in each animal. One week later the experiments were repeated with Visante OCT imaging. Accommodation was induced by pharmacological stimulation with corneal iontophoresis of 40% carbachol (CARB) in agar; a supramaximal dose for inducing accommodation.
Pharmacologically stimulated accommodation yielded a maximum accommodation of 2 and 6 diopters in respectively. In both animals maximum accommodation was reached 10 minutes after CARB administration with a rapid return to near baseline refractions at only 20 minutes. Both animals had accommodative anterior chamber shallowing as measured using UBM: 0.33mm(0.39-0.27) at two weeks post sectioning and OCT 0.54mm(0.65-0.43mm) at three weeks post sectioning. Plano perfusion lens imaging revealed a decrease in capsule diameter during accommodation in both animals of 0.59mm (0.52-0.65mm).
Zonular Capture Haptic based accommodative-disaccommodative IOL’s demonstrate a useful range of accommodation and significant axial shift in a first prototype, proof of concept IOL model.
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