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Ricardo Nose, Fabio Daga, Adriana Forseto, Gustavo Victor, Sidney Sousa, Walton Nose, Niro Kasahara; Optical coherence tomography analysis of hydrofluoric acid decontamination of human cornea by mannitol solution. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3891.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: to evaluate the efficacy of mannitol solution as decontamination agent on the chemical burn of the human cornea.
Methods: eight donor corneas from an eye bank were exposed to 25 μL of 2.5% hydrofluoric acid (HF) solution on a filter paper for 20 s. Three eyes were rinsed with 1000 ml of mannitol 20% for 15 min immediately after removal of the filter paper, 3 other were rinsed with tap water (1000 ml for 15 min) and two eyes were not rinsed. Microstructural changes were monitored in the time domain by OCT imaging for 90 min.
Results: tap water reduced the penetration depth to approximately half the thickness of the cornea at 15 min; scattering within the anterior cornea was higher than that for the unrinsed eye. With mannitol, no increased scattering is observed in the posterior part of the corneal stroma within a time period of 1 h after rinsing. OCT images revealed low-scattering intensity within the anterior stroma at the end of the rinsing period.
Conclusion: in eye bank human corneas, mannitol is an efficient agent to decontaminate HF burn.
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