June 2013
Volume 54, Issue 15
Free
ARVO Annual Meeting Abstract  |   June 2013
Relationship between Corneal Hysteresis and Visual Field Progression in Glaucoma and Ocular Hypertensive Eyes
Author Affiliations & Notes
  • Marta Pazos
    Ophthalmology. Glaucoma., Hospital de l'Esperança. Parc de Salut Mar., Barcelona, Spain
  • Alfonso Anton
    Ophthalmology. Glaucoma., Hospital de l'Esperança. Parc de Salut Mar., Barcelona, Spain
    Glaucoma. Research., Institut Català de la Retina., Barcelona, Spain
  • Maria Jesus López-Valladares
    Opthhalmology. Glaucoma., Complexo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain
  • Valentín Tinguaro Díaz-Alemán
    Opthalmology. Glaucoma., Hospital Universitario de Canarias, Tenerife, Spain
  • Monica Fallon
    Glaucoma. Research., Institut Català de la Retina., Barcelona, Spain
  • Footnotes
    Commercial Relationships Marta Pazos, None; Alfonso Anton, ALCON (F), SANTEN (C), MSD (C), THEA (C), TRANSCEND (C), ALCON (R), ALLERGAN (R), SANTEN (R); Maria Jesus López-Valladares, Allergan Inc (F), MSD (Merck Sharp and Dohme Spain) (R); Valentín Tinguaro Díaz-Alemán, None; Monica Fallon, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 3948. doi:
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      Marta Pazos, Alfonso Anton, Maria Jesus López-Valladares, Valentín Tinguaro Díaz-Alemán, Monica Fallon; Relationship between Corneal Hysteresis and Visual Field Progression in Glaucoma and Ocular Hypertensive Eyes. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3948.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To investigate if glaucomatous visual field progression is associated to corneal hysteresis parameters measured by the Ocular Response Analyzer (ORA).

Methods: One hundred glaucomatous and ocular hypertensive (OHT) patients previously analyzed for an ORA reproducibility study were prospectively evaluated in the basis of their standard follow-up care in the glaucoma clinic. Only patients with 3 years follow-up and a minimum of 5 Humphrey Standard 24-2visual fields (VF) were included. Guided Progression Analyzer (GPA) Visual Field Index (VFI) rate of progression (significant trend at p<0.05) and/or Progression Analysis Probability of events (three contiguous points significantly changing in at least two consecutive tests) were used to detect VF progression.

Results: 59 eyes (31 Glaucoma and 28 OHT, mean age 70.69±11.87 y; mean MD -2.95±4.7 dB; mean number of VF 8±2.45; mean follow-up time 4.10 ±0.64 y) met the enrolment criteria. The glaucoma group had significantly lower central corneal thickness (CCT) (531.42±30.9 vs 559.07±26.57μm, p<0.01) and lower corneal resistance factor (CRF) (9.16±1.61 vs 11.59±1.83, p<0.01) but not significantly different corneal hysteresis (CH) (8.66±2.16 vs 9.72±2.26, p=0.07) compared with the OHT group. The mean global VFI rate of progression was -0.57 ± 1.22 dB/year (Glaucoma:-1.05±1.5 vs OHT: -0.03±0.4 dB/year; p<0.01). Seventeen eyes reached a progression endpoint (2 in the OHT group and 15 in the Glaucoma group). Progressing eyes had greater baseline cup-to-disc ratio (0.66±0.2 vs 0.51±0.23; p<0.05), lower CCT (530±36.34 vs 550.4±36.3 μm; p<0.05) and lower CRF (9.31±1.27 vs; 10.72±2.25; p<0.05) but not significantly different CH (8.34±2.5 vs 9.50±2.1; p=0.07) compared with non-progressing eyes. Rate of progression, among progressing eyes, was significantly greater with decreasing CRF (r2 0.04, p<0.001).

Conclusions: Thinner CCT and lower CRF were associated with progressive field worsening in glaucomatous and OHT eyes.

Keywords: 758 visual fields • 479 cornea: clinical science  
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