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Michael Wall, Carrie Doyle, Trina Eden, Chris Johnson, Gideon Zamba; Detection of Glaucomatous Progression Comparing SITA Standard and Matrix Perimetry. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3955.
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The Humphrey Matrix may be more sensitive in detecting glaucomatous visual field loss compared to SITA-Standard. Therefore, it may be a good candidate to determine disease progression in glaucoma patients. Our aim was to test the hypothesis automated perimetry using the Humphrey Matrix would determine progression before SITA-Standard Size III.
Sixty normal subjects and 120 glaucoma patients were tested twice at baseline and every six months for 4 years with SITA-Standard size III and Matrix. We used a method of pointwise linear regression, PLRA2. With this approach, a glaucoma patient is defined as progressing if a significant slope was detected at the same test location in three of four consecutive visual field examinations with confirmed progression in two or more test locations. The 60 normals followed longitudinally were used to calculate specificity. Kaplan-Meier curves were used to compare the tests.
SITA-Standard testing detected visual field progression at a higher rate than the Humphrey Matrix (Figure). Using a slope of -1.0 dB per year at a p = 0.05 significance level, the hit rate/specificity ratios of size III were 18% and 100% and for Matrix were 12% and 97.7%.
SITA-Standard size III testing may identify glaucomatous visual field progression earlier than testing with the Humphrey Matrix.
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