June 2013
Volume 54, Issue 15
ARVO Annual Meeting Abstract  |   June 2013
Choroidal thickness in children with anisohypermetropic amblyopia
Author Affiliations & Notes
  • Tomo Nishi
    Ophthalmology, Nara medical university, Kashihara, Japan
  • Nahoko Ogata
    Ophthalmology, Nara medical university, Kashihara, Japan
  • Footnotes
    Commercial Relationships Tomo Nishi, None; Nahoko Ogata, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2013, Vol.54, 3998. doi:
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      Tomo Nishi, Nahoko Ogata; Choroidal thickness in children with anisohypermetropic amblyopia. Invest. Ophthalmol. Vis. Sci. 2013;54(15):3998.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: There are several reports about the retinal thickness in children with anisohypermetropic amblyopia but there are few reports about the choridal thickness. We compare the choroidal thickness in the macular area with anisohypermetropic amblyopic eyes and normal fellow eyes of anisohypermetropic amblyopic patients, and eyes of age-matched controls.

Methods: Twenty patients (6.6±2.2 years, mean±standard deviation years) with anisohypermetropic amblyopia and fifteen age-matched controls (7.2±3.3 years) were enrolled in this study. Enhanced depth imaging (EDI) was obtained by spectral-domain optical coherence tomography (OCT) in all patients and controls. The choroidal thickness was measured as a distance between the retinal pigment epithelium line and the chorioscleral interface (CSI). We measured beneath the subfoveal area and 1 and 3 mm diameter from the fovea in the superior, inferior, temporal, and nasal regions.

Results: The mean visual acuity (log MAR) was 0.29±0.16 in amblyopic eyes,-0.03±0.05 in normal fellow eyes, -0.09±0.06 in controls. The mean spherical equivalent (SE) was +4.25±1.88 diopter (D) in amblyopic eyes, +2.08±1.68 D in fellow eyes, and +1.25±2.34 D in controls. The mean axial length was 21.55±0.87mm in amblyopic eyes and 22.17±0.94mm in fellow eyes. The mean subfoveal choridal thickness(SFCT) was 358.83±46.97μm in amblyopic eyes, 292.12±58.10μm in normal fellow eyes, and 276.77±66.87μm in controls(P=0.001, ANOVA). The choroid was thicker in amblyopic eyes compared to that of fellow eyes and control eyes. Choroidal thickness in the superior region was thicker than that of nasal region of 3mm diameter from the fovea in both groups. There was a positive correlation between laterality of choroidal thickness and that of axial legth in ambyopic group (r=0.76, P=0.001, Pearson`s correlation coefficient). The laterality of SFCT in amblyopic group was larger than that in control group (P=0.01, paired t-test).

Conclusions: The choroid was thicker in anisohypermetropic amblyopia eyes. This may suggest a contributing role of the perfusion of the choroid in the pathogenesis of amblyopia.

Keywords: 417 amblyopia • 452 choroid • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)  

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