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Shuntaro Ogura, Tsutomu Yasukawa, Munenori Yoshida, Yuichiro Ogura; Ultra wide-field autofluorescence is useful to evauluate residual retinal functions in patients with Retinitis Pigmentosa. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4020.
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To investigate the correlation between the visual field (VF) tested by Goldmann perimetry (GP) and ultra wide-field fundus autofluorescence (FAF) in patients with retinitis pigmentosa (RP).
In this pilot study, 20 eyes of 10 patients diagnosed as RP were enrolled. GP and ultra wide-field FAF images with Optos®200Tx (Optos) were evaluated for each eye. The areas of absent autofluorescence in FAF were correlated with the areas of scotoma in GP. GP and FAF images were then superimposed and the agreement ratio in the central 60 degrees of VF was evaluated.
The areas of absent autofluorescence in FAF were significantly correlated with the areas of scotoma (I4e/V4e isopters) in GP (R=0.86, P<0.000001). The agreement ratio of absent autofluorescence and the scotoma in the central 60 degrees was 88.7±11.5% of VF. In addition, the agreement ratio of normal autofluorescence and remaining VF (V4e) was 87.1±8.7% of VF as well. Irregular or abnormal autofluorescence was seen in 7 eyes at the border of normal and absent autofluorescence while the VF was normal in those areas.
These results suggested that FAF imaging by Optos is very useful to evaluate residual retinal functions in patients with RP. Abnormal fundus autofluorescence might precede the loss of retinal functions and be helpful to monitor for the progression of the disease.
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