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Yukimi Yamamoto, Dai Miyazaki, Shin-ichi Sasaki, Ken-ichiro Miyake, Shuzo Kaneda, Yoshifumi Ikeda, Atsushi Yamasaki, Yoshitsugu Inoue; Associations of IL-10 with Choroidal Neovascularization in high myopia. Invest. Ophthalmol. Vis. Sci. 2013;54(15):4129.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the relationship between the levels of intraocular inflammatory cytokines and choroidal neovascularization in high myopia.
Prospective cohort study. Choroidal neovascularization (CNV) in patients with high myopia (axial length ≥ 26.5 mm) was defined as myopic CNV (mCNV). Forty one patients with mCNV and 44 control subjects were studied. The levels of VEGF, MCP-1, IL-4, IL-10, and IL-23 in the aqueous humor samples from mCNV patients and control subjects were assessed for significant associations with mCNV. Logistic regression analysis was used to compute the odds ratios (ORs) and 95% confidence intervals (CIs).
Axial length significantly correlated with levels of MCP-1 and IL-4 by Spearman correlation analysis (MCP-1: ρ=0.36, P=0.003, IL-4: ρ=0.33, P=0.009). In contrast, VEGF, IL-10, and IL-23 levels were independent of axial length. In mCNV patients, IL-10, IL-4, and MCP-1 were significantly higher than that in the controls (P=0.005, P=0.04, P=0.047, respectively). The IL-10 elevation was associated with mCNV and provided significant OR after age adjustment, however, no other cytokines discriminated the disease.
The significant association between elevated levels of IL-10 with mCNV strongly suggests an involvement of inflammatory processes in the etiology of mCNV presumably independent of VEGF or axial length.
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